F5053
含黄素的单加氧酶3，微粒体 人
recombinant, expressed in baculovirus infected insect cells, buffered aqueous solution
别名:
FMO-3
产品名称
含黄素的单加氧酶3，微粒体 人, recombinant, expressed in baculovirus infected insect cells, buffered aqueous solution
recombinant
expressed in baculovirus infected insect cells
form
buffered aqueous solution
mol wt
55-60 kDa
packaging
vial of 2.5 mg
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Quality Level
Gene Information
human ... FMO3(2328)
Application
FMO3是主要的人肝脏形式。
Biochem/physiol Actions
含黄素单加氧酶-3 (FMO3)可促进几种药物、化学品和外源性物质的氧化。人FMO3也参与了由三甲胺(TMA)合成三甲胺(TMAO)的N-氧化物。FMO3基因突变与臭鱼症或鱼腥症有关。FMO3基因的缺失可导致血浆TMAO水平降低，从而降低动脉粥样硬化和血栓形成的风险。
General description
含黄素单加氧酶-3 (FMO3)是含黄素单加氧酶(FMO)家族中的一员。它在人类肝脏中高度表达。
Physical form
溶于100 mM磷酸钾缓冲液，pH 7.4的溶液
存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
此项目有
Irfan M Hisamuddin et al.
Pharmacogenomics, 8(6), 635-643 (2007-06-15)
Flavin-containing monooxygenase 3 (FMO3) is a hepatic microsomal enzyme that oxidizes a host of drugs, xenobiotics and other chemicals. Numerous variants in the gene encoding FMO3 have been identified, some of which result in altered enzymatic activity and, consequently, altered
Chongliang Gao et al.
Scientific reports, 7(1), 14668-14668 (2017-11-09)
Human flavin-containing monooxygenase 3 (hFMO3) catalyses the oxygenation of a wide variety of compounds including drugs as well as dietary compounds. It is the major hepatic enzyme involved in the production of the N-oxide of trimethylamine (TMAO) and clinical studies
W Zhu et al.
Journal of thrombosis and haemostasis : JTH, 16(9), 1857-1872 (2018-07-08)
Essentials Microbe-dependent production of trimethylamine N-oxide (TMAO) contributes to thrombosis risk. The impact of host flavin monooxygenase 3 (FMO3) modulation on platelet function is unknown. Genetic manipulation of FMO3 in mice alters systemic TMAO levels and thrombosis potential. Genetic manipulation
Robert R Reddy et al.
Drug metabolism and disposition: the biological fate of chemicals, 38(12), 2239-2245 (2010-09-03)
The flavin-containing monooxygenase (FMO) family of enzymes oxygenates nucleophilic xenobiotics and endogenous substances. Human FMO3 and FMO5 are the predominant FMO forms in adult liver. These enzymes are naturally membrane-bound, and recombinant proteins are commercially available as microsomal preparations from
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