F5053
含黄素的单加氧酶3，微粒体 人
recombinant, expressed in baculovirus infected insect cells, buffered aqueous solution
别名:
FMO-3
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recombinant
expressed in baculovirus infected insect cells
Quality Level
form
buffered aqueous solution
mol wt
55-60 kDa
packaging
vial of 2.5 mg
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... FMO3(2328)
General description
含黄素单加氧酶-3 (FMO3)是含黄素单加氧酶(FMO)家族中的一员。它在人类肝脏中高度表达。
Application
FMO3是主要的人肝脏形式。
Biochem/physiol Actions
含黄素单加氧酶-3 (FMO3)可促进几种药物、化学品和外源性物质的氧化。人FMO3也参与了由三甲胺(TMA)合成三甲胺(TMAO)的N-氧化物。FMO3基因突变与臭鱼症或鱼腥症有关。FMO3基因的缺失可导致血浆TMAO水平降低，从而降低动脉粥样硬化和血栓形成的风险。
Physical form
溶于100 mM磷酸钾缓冲液，pH 7.4的溶液
存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
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相关内容
Datasheet
W Zhu et al.
Journal of thrombosis and haemostasis : JTH, 16(9), 1857-1872 (2018-07-08)
Essentials Microbe-dependent production of trimethylamine N-oxide (TMAO) contributes to thrombosis risk. The impact of host flavin monooxygenase 3 (FMO3) modulation on platelet function is unknown. Genetic manipulation of FMO3 in mice alters systemic TMAO levels and thrombosis potential. Genetic manipulation
Chongliang Gao et al.
Scientific reports, 7(1), 14668-14668 (2017-11-09)
Human flavin-containing monooxygenase 3 (hFMO3) catalyses the oxygenation of a wide variety of compounds including drugs as well as dietary compounds. It is the major hepatic enzyme involved in the production of the N-oxide of trimethylamine (TMAO) and clinical studies
Irfan M Hisamuddin et al.
Pharmacogenomics, 8(6), 635-643 (2007-06-15)
Flavin-containing monooxygenase 3 (FMO3) is a hepatic microsomal enzyme that oxidizes a host of drugs, xenobiotics and other chemicals. Numerous variants in the gene encoding FMO3 have been identified, some of which result in altered enzymatic activity and, consequently, altered
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| F5053-1VL | 04061826303979 |