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Merck
CN

F5132

Sigma-Aldrich

Factor II 来源于人类血浆

lyophilized powder, 5-20 units/mg protein

别名:

Prothrombin

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表单

lyophilized powder

比活

5-20 units/mg protein

UniProt登记号

异质活性

factor X <0.01% of base activity
thrombin, none detected

储存温度

−20°C

基因信息

human ... F2(2147)

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生化/生理作用

Plasma phospholipid binding protein; binds to endothelial cells, promotes clotting on the cell surfaces.

制备说明

When reconstituted with 1 ml of deionized water, solution will contain the indicated activity in 0.5 M NaCl, 0.05 M Tris-HCl, pH 8.0.

其他说明

One unit is the amount contained in one mL of normal human plasma.

法规信息

新产品

历史批次信息供参考:

分析证书(COA)

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G V Papatheodoridis et al.
Journal of hepatology, 31(4), 747-750 (1999-11-07)
We evaluated the efficacy of recombinant factor VII to correct impaired haemostasis in a patient with liver cirrhosis requiring an invasive procedure. A test intravenous bolus of 80 microg/kg of recombinant factor VII was given to a Jehovah's Witness, with
Raúl H Morales-Borges
Puerto Rico health sciences journal, 31(4), 232-234 (2013-07-13)
Splenic infarction is rare and the prothrombin gene mutation (PGM) is not commonly observed in Puerto Rico. PGM is present in 1% of the general population, and in 7% of the people with deep venous thrombosis (DVT); it is found
S L Field et al.
Blood, 94(10), 3421-3431 (1999-11-24)
Lupus anticoagulants (LA) are a family of autoantibodies that are associated with in vitro anticoagulant activity but a strong predisposition to in vivo thrombosis. They are directed against plasma phospholipid binding proteins, including prothrombin. We found that a murine monoclonal
Y Zhao et al.
Arthritis and rheumatism, 42(10), 2132-2138 (1999-10-19)
To test the hypothesis that some lupus anticoagulants are antiprothrombin antibodies, and that such antibodies enhance prothrombin binding to endothelial cells (EC) and thus promote clotting on the cell surface. We generated a monoclonal antiprothrombin antibody (designated IS6) from a
Ayako Tomono et al.
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 110(5), 852-860 (2013-05-08)
A 78-year-old man was admitted for workup for a liver tumor. Both serum AFP and PIVKA-II levels were high (2260ng/ml and 806mAU/ml, respectively). Contrast-enhanced CT scan and MRI using Gd-EOB-DTPA demonstrated a liver tumor in segment 6 resembling the imaging

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