Biochem/physiol Actions
Plasma phospholipid binding protein; binds to endothelial cells, promotes clotting on the cell surfaces.
Other Notes
One unit is the amount contained in one mL of normal human plasma.
Preparation Note
When reconstituted with 1 ml of deionized water, solution will contain the indicated activity in 0.5 M NaCl, 0.05 M Tris-HCl, pH 8.0.
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G V Papatheodoridis et al.
Journal of hepatology, 31(4), 747-750 (1999-11-07)
We evaluated the efficacy of recombinant factor VII to correct impaired haemostasis in a patient with liver cirrhosis requiring an invasive procedure. A test intravenous bolus of 80 microg/kg of recombinant factor VII was given to a Jehovah's Witness, with
Raúl H Morales-Borges
Puerto Rico health sciences journal, 31(4), 232-234 (2013-07-13)
Splenic infarction is rare and the prothrombin gene mutation (PGM) is not commonly observed in Puerto Rico. PGM is present in 1% of the general population, and in 7% of the people with deep venous thrombosis (DVT); it is found
S L Field et al.
Blood, 94(10), 3421-3431 (1999-11-24)
Lupus anticoagulants (LA) are a family of autoantibodies that are associated with in vitro anticoagulant activity but a strong predisposition to in vivo thrombosis. They are directed against plasma phospholipid binding proteins, including prothrombin. We found that a murine monoclonal
Y Zhao et al.
Arthritis and rheumatism, 42(10), 2132-2138 (1999-10-19)
To test the hypothesis that some lupus anticoagulants are antiprothrombin antibodies, and that such antibodies enhance prothrombin binding to endothelial cells (EC) and thus promote clotting on the cell surface. We generated a monoclonal antiprothrombin antibody (designated IS6) from a
R Filipčíková et al.
Ceska gynekologie, 78(1), 73-77 (2013-04-24)
To assess and compare the frequency of selected gene mutations of thrombophilic markers (FV Leiden, FII prothrombin G20210A and MTHFR C677T) in patients with primary and secondary infertility. Retrospective study. Institute of normal anatomy, Faculty of Medicine and Dentistry, Palacky
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