F5557
Fasentin
≥98% (HPLC)
别名:
N-[4-氯-3-(三氟甲基)苯基]-3-氧代丁酰胺
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关于此项目
经验公式（希尔记法）:
C11H9ClF3NO2
化学文摘社编号:
分子量:
279.64
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
Fasentin, ≥98% (HPLC)
InChI
1S/C11H9ClF3NO2/c1-6(17)4-10(18)16-7-2-3-9(12)8(5-7)11(13,14)15/h2-3,5H,4H2,1H3,(H,16,18)
SMILES string
CC(=O)CC(=O)Nc1ccc(Cl)c(c1)C(F)(F)F
InChI key
GNYIJZMBLZXJEJ-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to off-white
solubility
DMSO: >10 mg/mL
storage temp.
room temp
Quality Level
相关类别
Application
Fasentin已被用作葡萄糖转运蛋白（GLUT1）抑制剂，用于评估其对各种三阴性乳腺癌 (TNBC) 细胞系脆弱性的影响，并研究其对氢化可的松（HC）诱发的细胞毒性药物的作用。
Biochem/physiol Actions
Fastentin是一种全新的葡萄糖摄入抑制剂，GluT1抑制剂。
Fastentin是一种葡萄糖摄入的全新抑制剂，GluT1抑制剂。Fastentin是一种全新的葡萄糖摄入抑制剂，可敏化细胞对FAS诱导的细胞死亡。Fastentin会选择性敏化死亡配体，但不会降低FLIP的表达。它会改变与营养和葡萄糖剥夺相关的基因表达。Fastentin可与葡萄糖转运蛋白GLUT1细胞间通道中一个独特的位点发生互作。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Eleni Louka et al.
The Journal of experimental medicine, 218(2) (2021-01-09)
Juvenile myelomonocytic leukemia (JMML) is a poor-prognosis childhood leukemia usually caused by RAS-pathway mutations. The cellular hierarchy in JMML is poorly characterized, including the identity of leukemia stem cells (LSCs). FACS and single-cell RNA sequencing reveal marked heterogeneity of JMML
Dominik Kraus et al.
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In our study, ghrelin was investigated with respect to its capacity on proliferative effects and molecular correlations on oral tumor cells. The presence of all molecular components of the ghrelin system, i.e., ghrelin and its receptors, was analyzed and could
Qin Wu et al.
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Triple negative breast cancer (TNBC) is a deadly form of breast cancer due to the development of resistance to chemotherapy affecting over 30% of patients. New therapeutics and companion biomarkers are urgently needed. Recognizing the elevated expression of glucose transporter
Antonio Celentano et al.
Journal of cellular physiology, 234(3), 2013-2020 (2018-09-22)
Synthetic corticosteroids are routinely administered during the treatment of several diseases, including malignancies. However, recent evidence suggests that corticosteroids may have tumor-promoting effects, particularly in epithelial neoplasms. Our aim was to assess the role of the recently characterized cancer-associated glucocorticoid
商品
Warburg effect enhances glucose to lactate conversion in tumor cells, regardless of oxygen levels; impacting cancer metabolism since 1924.
本页面介绍了一篇有关瓦博格效应的文章，以及其如何能够在正常氧气水平下，增强肿瘤细胞中葡萄糖向乳酸的转化。Otto Heinrich Warburg在1924年证明，癌细胞显示出对糖酵解的依赖性增加，以满足他们的能量需求，无论是否有充足的氧气存在。
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