F6127
醋酸氟可的松
synthetic, ≥98%, glucocorticoid activity, powder
别名:
9α-Fluoro-11β,17α,21-trihydroxy-4-pregnene-3,20-dione acetate, 9-Fluorocortisol acetate, 9-Fluorohydrocortisone acetate
产品名称
醋酸氟可的松, ≥98%
生物来源
synthetic
无菌性
non-sterile
方案
≥98%
表单
powder
溶解性
acetone: 50 mg/mL, clear, colorless to light yellow
运输
ambient
储存温度
room temp
SMILES字符串
CC(=O)OCC(=O)[C@@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]12C
InChI
1S/C23H31FO6/c1-13(25)30-12-19(28)22(29)9-7-16-17-5-4-14-10-15(26)6-8-20(14,2)23(17,24)18(27)11-21(16,22)3/h10,16-18,27,29H,4-9,11-12H2,1-3H3/t16-,17-,18-,20-,21-,22-,23-/m0/s1
InChI key
SYWHXTATXSMDSB-GSLJADNHSA-N
基因信息
human ... NR3C2(4306)
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一般描述
Fludrocortisone acetate is secreted by adrenal cortex. It increases the reabsorption of sodium and secretion of potassium and hydrogen. Fludrocortisone is used to treat cerebral salt wasting syndrome and adrenal insufficiency. Fludrocortisone improves the sensitivity of blood vessels to catecholamines and increases the blood volume.
生化/生理作用
Fludrocortisone acetate is a synthetic corticosteroid with more mineralocorticoid than glucocorticoid activity.
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral - Repr. 2
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
G G Krishna et al.
Kidney international, 43(5), 1097-1103 (1993-05-01)
Potassium depletion induced by dietary potassium restriction causes sodium retention while potassium supplementation augments urinary sodium excretion. The role of external potassium balance in modulating mineralocorticoid-induced sodium retention in humans is unknown. Accordingly, eight healthy subjects were studied at the
Ichiro Nakagawa et al.
Cerebrovascular diseases (Basel, Switzerland), 35(2), 131-137 (2013-02-15)
Hyponatremia is a common complication occurring in one third of patients after subarachnoid hemorrhage (SAH). One mechanism that likely mediates the development of hyponatremia in SAH is cerebral salt wasting syndrome (CSWS), which induces natriuresis and reduces total blood volume
Fludrocortisone therapy in cerebral salt wasting
Taplin CE, et al.
Pediatrics, 118(6), e1904-e1908 (2006)
Shreya Ghimire et al.
Scientific reports, 11(1), 19438-19438 (2021-10-02)
RNA sequencing enables high-content/high-complexity measurements in small molecule screens. Whereas the costs of DNA sequencing and RNA-seq library preparation have decreased consistently, RNA extraction remains a significant bottleneck to scalability. We evaluate the performance of a bulk RNA-seq library prep
Stéphane Gibaud et al.
International journal of pharmaceutics, 269(2), 491-508 (2004-01-07)
Substitutive hormonal therapies have to be administered for long periods. Thus, the development of sustained-release forms, as microparticle suspensions, is interesting in order to improve patient compliance by reducing dosing frequencies and side effects. The aim of this work was
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