F6127
醋酸氟可的松
synthetic, ≥98%, glucocorticoid activity, powder
别名:
9α-Fluoro-11β,17α,21-trihydroxy-4-pregnene-3,20-dione acetate, 9-Fluorocortisol acetate, 9-Fluorohydrocortisone acetate
Product Name
醋酸氟可的松, ≥98%
生物来源
synthetic
质量水平
无菌性
non-sterile
方案
≥98%
表单
powder
溶解性
acetone: 50 mg/mL, clear, colorless to light yellow
运输
ambient
储存温度
room temp
SMILES字符串
CC(=O)OCC(=O)[C@@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]12C
InChI
1S/C23H31FO6/c1-13(25)30-12-19(28)22(29)9-7-16-17-5-4-14-10-15(26)6-8-20(14,2)23(17,24)18(27)11-21(16,22)3/h10,16-18,27,29H,4-9,11-12H2,1-3H3/t16-,17-,18-,20-,21-,22-,23-/m0/s1
InChI key
SYWHXTATXSMDSB-GSLJADNHSA-N
基因信息
human ... NR3C2(4306)
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一般描述
Fludrocortisone acetate is secreted by adrenal cortex. It increases the reabsorption of sodium and secretion of potassium and hydrogen. Fludrocortisone is used to treat cerebral salt wasting syndrome and adrenal insufficiency. Fludrocortisone improves the sensitivity of blood vessels to catecholamines and increases the blood volume.
生化/生理作用
Fludrocortisone acetate is a synthetic corticosteroid with more mineralocorticoid than glucocorticoid activity.
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral - Repr. 2
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Fludrocortisone therapy in cerebral salt wasting
Taplin CE, et al.
Pediatrics, 118(6), e1904-e1908 (2006)
H J Van der Kamp et al.
Archives of disease in childhood, 87(2), 139-144 (2002-07-26)
To evaluate growth from diagnosis until final height (FH) in 21-hydroxylase deficiency patients. A retrospective longitudinal study was performed. Only patients treated with hydrocortisone and fludrocortisone (in case of salt wasting) were evaluated. This resulted in a sample of 34
Shreya Ghimire et al.
Scientific reports, 11(1), 19438-19438 (2021-10-02)
RNA sequencing enables high-content/high-complexity measurements in small molecule screens. Whereas the costs of DNA sequencing and RNA-seq library preparation have decreased consistently, RNA extraction remains a significant bottleneck to scalability. We evaluate the performance of a bulk RNA-seq library prep
Cecilia Mattsson et al.
Nature clinical practice. Nephrology, 2(4), 198-208 (2006-08-26)
Primary aldosteronism is caused by bilateral idiopathic hyperplasia in approximately two-thirds of cases and aldosterone-producing adenoma in one-third. Most patients with primary aldosteronism are normokalemic. In the clinical setting of normokalemic hypertension, patients who have resistant hypertension and hypertensive patients
Aruna V Krishnan et al.
Endocrinology, 143(5), 1889-1900 (2002-04-17)
The cortisol/cortisone-responsive AR (AR(ccr)) has two mutations (L701H and T877A) that were found in the MDA PCa human prostate cancer cell lines established from a castrated patient whose metastatic tumor exhibited androgen-independent growth. Cortisol and cortisone bind to the AR(ccr)
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