F6127
醋酸氟可的松
synthetic, ≥98%, glucocorticoid activity, powder
别名:
9α-Fluoro-11β,17α,21-trihydroxy-4-pregnene-3,20-dione acetate, 9-Fluorocortisol acetate, 9-Fluorohydrocortisone acetate
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关于此项目
经验公式（希尔记法）:
C23H31FO6
化学文摘社编号:
分子量:
422.49
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
208-180-4
MDL number:
产品名称
醋酸氟可的松, ≥98%
InChI key
SYWHXTATXSMDSB-GSLJADNHSA-N
InChI
1S/C23H31FO6/c1-13(25)30-12-19(28)22(29)9-7-16-17-5-4-14-10-15(26)6-8-20(14,2)23(17,24)18(27)11-21(16,22)3/h10,16-18,27,29H,4-9,11-12H2,1-3H3/t16-,17-,18-,20-,21-,22-,23-/m0/s1
SMILES string
CC(=O)OCC(=O)[C@@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]12C
biological source
synthetic
sterility
non-sterile
assay
≥98%
form
powder
solubility
acetone: 50 mg/mL, clear, colorless to light yellow
shipped in
ambient
storage temp.
room temp
Quality Level
Gene Information
human ... NR3C2(4306)
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Biochem/physiol Actions
Fludrocortisone acetate is a synthetic corticosteroid with more mineralocorticoid than glucocorticoid activity.
General description
Fludrocortisone acetate is secreted by adrenal cortex. It increases the reabsorption of sodium and secretion of potassium and hydrogen. Fludrocortisone is used to treat cerebral salt wasting syndrome and adrenal insufficiency. Fludrocortisone improves the sensitivity of blood vessels to catecholamines and increases the blood volume.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Repr. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock
Annane D, et al.
JAMA : The Journal of the American Medical Association, 288(7), 862-871 (2002)
S Yamashiro et al.
Acta neurochirurgica, 139(10), 987-990 (1997-01-01)
This 67 year-old man experienced 3 episodes of symptomatic hyponatraemia. Radiological examination revealed a sellar lesion and the tumour was removed via the transsphenoidal route. Thereafter, he simultaneously developed intractable diabetes insipidus and serious hyponatraemia with persistent natriuresis. His level
R Taniguchi et al.
The Tohoku journal of experimental medicine, 186(3), 215-223 (1999-05-29)
It is known that some patients with primary aldosteronism show postoperative hyperkalemia, which is due to inability of the adrenal gland to secrete sufficient amounts of aldosterone. However, hyperkalemia is generally neither severe nor prolonged, in which replacement therapy with
Clinical Pharmacology Made Incredibly Easy! (2009)
Dong-Min Kim et al.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 22(11), 3273-3276 (2007-07-10)
Hyperkalaemia is a commonly encountered problem in dialysis patients with end-stage renal disease (ESRD). The aim of the present study was to assess the effect of fludrocortisone acetate (FCA) on reducing serum potassium levels in haemodialysis (HD) patients with hyperkalaemia.
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