F6771
Fumagillin
from Aspergillus sp. (Aspergillus fumigatus), ≥90% (HPLC), powder, MetAP2 inhibitor
别名:
Fugillin
并加购，请在购物车里查看协议价、货期和发货地。
选择规格
变更视图
关于此项目
经验公式（希尔记法）:
C26H34O7
化学文摘社编号:
分子量:
458.54
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
EC Number:
245-433-8
MDL number:
Assay:
≥90%
Form:
powder
产品名称
Fumagillin from Aspergillus fumigatus, ≥90%, powder
biological source
Aspergillus sp. (Aspergillus fumigatus)
Quality Segment
assay
≥90%
form
powder
color
white
mp
197-198 °C
solubility
ethanol: 1 mg/mL
antibiotic activity spectrum
fungi
mode of action
DNA synthesis | interferes
storage temp.
−20°C
SMILES string
COC1C(CCC2(CO2)C1C3(C)OC3C\C=C(\C)C)OC(=O)\C=C\C=C\C=C\C=C\C(O)=O
InChI
1S/C26H34O7/c1-18(2)13-14-20-25(3,33-20)24-23(30-4)19(15-16-26(24)17-31-26)32-22(29)12-10-8-6-5-7-9-11-21(27)28/h5-13,19-20,23-24H,14-17H2,1-4H3,(H,27,28)/b7-5+,8-6+,11-9+,12-10+
InChI key
NGGMYCMLYOUNGM-HCNIIHBUSA-N
General description
Fumagillin is a metabolic product of fungi. It is originally isolated from Aspergillus fumigatus.
Application
Fumagillin from Aspergillus fumigatus has been used:
- in chick chorioallantoic membrane (CAM) assay to study the changes in protein expression in response to anti-angiogenic agent
- to study its effects on the mortality of caged Nosema ceranae-infected honey bees- write in this way
- as a positive control in in vitro and ex vivo studies
Biochem/physiol Actions
Fumagillin is known to be effective against microsporidian fungal infections.
Methionine aminopeptidase-2 (MetAP-2) inhibitor; inhibits endothelial cell proliferation and angiogenesis.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves