F6771
Fumagillin
from Aspergillus sp. (Aspergillus fumigatus), ≥90% (HPLC), powder, MetAP2 inhibitor
别名:
Fugillin
登录 查看公司和协议定价
选择尺寸
关于此项目
经验公式（希尔记法）:
C26H34O7
化学文摘社编号:
分子量:
458.54
EC 号:
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
产品名称
Fumagillin from Aspergillus fumigatus, ≥90%, powder
生物来源
Aspergillus sp. (Aspergillus fumigatus)
质量水平
方案
≥90%
表单
powder
颜色
white
mp
197-198 °C
溶解性
ethanol: 1 mg/mL
抗生素抗菌谱
fungi
作用机制
DNA synthesis | interferes
储存温度
−20°C
SMILES字符串
COC1C(CCC2(CO2)C1C3(C)OC3C\C=C(\C)C)OC(=O)\C=C\C=C\C=C\C=C\C(O)=O
InChI
1S/C26H34O7/c1-18(2)13-14-20-25(3,33-20)24-23(30-4)19(15-16-26(24)17-31-26)32-22(29)12-10-8-6-5-7-9-11-21(27)28/h5-13,19-20,23-24H,14-17H2,1-4H3,(H,27,28)/b7-5+,8-6+,11-9+,12-10+
InChI key
NGGMYCMLYOUNGM-HCNIIHBUSA-N
一般描述
Fumagillin is a metabolic product of fungi. It is originally isolated from Aspergillus fumigatus.
应用
Fumagillin from Aspergillus fumigatus has been used:
- in chick chorioallantoic membrane (CAM) assay to study the changes in protein expression in response to anti-angiogenic agent
- to study its effects on the mortality of caged Nosema ceranae-infected honey bees- write in this way
- as a positive control in in vitro and ex vivo studies
生化/生理作用
Fumagillin is known to be effective against microsporidian fungal infections.
Methionine aminopeptidase-2 (MetAP-2) inhibitor; inhibits endothelial cell proliferation and angiogenesis.
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
涉药品监管产品
此项目有
A novel technique for quantifying changes in vascular density, endothelial cell proliferation and protein expression in response to modulators of angiogenesis using the chick chorioallantoic membrane (CAM) assay
Miller WJ, et al.
Journal of Translational Medicine, 2(1), 4-4 (2004)
The effect of dicyclohexylamine and fumagillin on Nosema ceranae-infected honey bee (Apis mellifera) mortality in cage trial assays
Van den Heever JP, et al.
Apidologie, 47(5), 663-670 (2016)
Fumagillin: an overview of recent scientific advances and their significance for apiculture
van den Heever JP, et al.
Journal of Agricultural and Food Chemistry, 62(13), 2728-2737 (2014)
Daniel J Kass et al.
PloS one, 7(4), e35388-e35388 (2012-04-18)
Pulmonary Hypertension (PH) is a pathophysiologic condition characterized by hypoxemia and right ventricular strain. Proliferation of fibroblasts, smooth muscle cells, and endothelial cells is central to the pathology of PH in animal models and in humans. Methionine aminopeptidase-2 (MetAP2) regulates
S-Q Yin et al.
Current medicinal chemistry, 19(7), 1021-1035 (2012-01-11)
Methionine aminopeptidases (MetAPs), which remove methionine residue from newly synthesized polypeptide chains, are a class of metalloproteases ubiquitously distributed in both eukaryotes and prokaryotes. MetAP-2 inhibition can induce G1 cell cycle arrest, cytostasis in tumor cells in vitro and inhibition
相关内容
Product Information Sheet
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持