F7016
氟甲喹
≥97.0% (HPLC)
别名:
9-Fluoro-5-methyl-1-oxo-1,5,6,7-tetrahydropyrido[3,2,1-ij]quinoline-2-carboxylic acid
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关于此项目
经验公式（希尔记法）:
C14H12FNO3
化学文摘社编号:
分子量:
261.25
UNSPSC Code:
51102829
NACRES:
NA.85
PubChem Substance ID:
EC Number:
255-962-6
Beilstein/REAXYS Number:
490724
MDL number:
assay
≥97.0% (HPLC)
form
powder
color
white to off-white
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria
mode of action
DNA synthesis | interferes, enzyme | inhibits
SMILES string
CC1CCc2cc(F)cc3C(=O)C(=CN1c23)C(O)=O
InChI
1S/C14H12FNO3/c1-7-2-3-8-4-9(15)5-10-12(8)16(7)6-11(13(10)17)14(18)19/h4-7H,2-3H2,1H3,(H,18,19)
InChI key
DPSPPJIUMHPXMA-UHFFFAOYSA-N
General description
化学结构：氟喹诺酮
Biochem/physiol Actions
泛黄素抑制拓扑异构酶，这是细菌 DNA 转录和复制所必需的。拓扑异构酶的抑制导致细菌染色体的链断裂、超螺旋和重新封闭。因此，DNA 复制和转录被抑制。
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Yoko Kashida et al.
Toxicological sciences : an official journal of the Society of Toxicology, 69(2), 317-321 (2002-10-16)
In order to elucidate the tumor-initiating potential of flumequine (FL) in the liver, male C3H mice were given dietary administration of 4000 ppm FL throughout the study or for 2 weeks at the initiation stage, and then received 2 intraperitoneal
Etienne Giraud et al.
Journal of medical microbiology, 53(Pt 9), 895-901 (2004-08-18)
The mechanisms of resistance to quinolone and epidemiological relationships among A. salmonicida strains isolated from diseased fish in French marine farms from 1998 to 2000 were investigated. The quinolone resistance-determining regions of the gyrA and parC genes of 12 clinical
I Guillemin et al.
Microbiology (Reading, England), 145 ( Pt 9), 2527-2532 (1999-10-12)
The DNA gyrases from Mycobacterium avium, Mycobacterium smegmatis and Mycobacterium fortuitum bv. peregrinum, which are species naturally resistant, moderately susceptible and susceptible to fluoroquinolones, respectively, were purified by affinity chromatography on novobiocin-Sepharose columns. The DNA gyrase inhibiting activities (IC50 values)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| F7016-5G | 04061833619247 |
| F7016-1G | 04061833619223 |