F7751

氟甲睾酮

Name: 氟甲睾酮
Brand: SIGMA

solid (photosensitive)

别名:

11β,17β-Dihydroxy-9α-fluoro-17α-methyl-4-androsten-3-one, 9α-Fluoro-11β,17β-dihydroxy-17α-methylandrost-4-en-3-one, 9α-Fluoro-11β-hydroxy-17α-methyltestosterone

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关于此项目

经验公式（希尔记法）:

C₂₀H₂₉FO₃

化学文摘社编号:

76-43-7

分子量:

336.44

UNSPSC Code:

51111800

PubChem Substance ID:

24894947

EC Number:

200-961-8

MDL number:

MFCD00010480

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产品名称

氟甲睾酮, solid (photosensitive)

InChI key

YLRFCQOZQXIBAB-RBZZARIASA-N

InChI

1S/C20H29FO3/c1-17-8-6-13(22)10-12(17)4-5-15-14-7-9-19(3,24)18(14,2)11-16(23)20(15,17)21/h10,14-16,23-24H,4-9,11H2,1-3H3/t14-,15-,16-,17-,18-,19-,20-/m0/s1

SMILES string

[H][C@@]12CC[C@](C)(O)[C@@]1(C)C[C@H](O)[C@@]3(F)[C@@]2([H])CCC4=CC(=O)CC[C@]34C

biological source

Porcine pancreas
bovine milk (other parts like skeletal muscle/bile/bone/connective tissue/skin)
microbial (Mycobacterium sp.)

form

solid (photosensitive)

drug control

USDEA Schedule III; Home Office Schedule 4.2; regulated under CDSA - not available from Sigma-Aldrich Canada

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

color

white

solubility

H₂O: ≤0.5 mg/mL
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 6.4 mg/mL
ethanol: 7.3 mg/mL

application(s)

forensics and toxicology
veterinary

shipped in

ambient

storage temp.

room temp

Gene Information

human ... AR(367), ESR1(2099), PRLR(5618)

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Biochem/physiol Actions

Fluoxymesterone is an androgen and anabolic steroid.

pictograms

GHS08

signalword

Warning

hcodes

H361

pcodes

P281

Hazard Classifications

Repr. 2

存储类别

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

法规信息

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Eastern Cooperative Oncology Group randomized trials of observation versus maintenance therapy for patients with metastatic breast cancer in complete remission following induction treatment.

G Falkson et al.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 16(5), 1669-1676 (1998-05-20)

To investigate the value of maintenance treatment for patients with metastatic breast cancer whose disease is in complete remission (CR). One hundred ninety-five women (141 eligible) whose disease was in CR or in CR except for bone metastases following six

Elucidation of urinary metabolites of fluoxymesterone by liquid chromatography-tandem mass spectrometry and gas chromatography-mass spectrometry.

Oscar J Pozo et al.

Journal of mass spectrometry : JMS, 43(3), 394-408 (2007-11-27)

The suitability of liquid chromatography tandem mass spectrometry (LC-MS/MS) and gas chromatography mass spectrometry (GC-MS) for the elucidation of fluoxymesterone metabolism has been evaluated. Electrospray ionization (ESI) and collision induced dissociation (CID) fragmentation in LC-MS/MS and electron impact spectra (EI)

Amenorrhea induced by adjuvant chemotherapy in early breast cancer patients: prognostic role and clinical implications.

L Del Mastro et al.

Breast cancer research and treatment, 43(2), 183-190 (1997-04-01)

The role of amenorrhea induced by chemotherapy in premenopausal women with early breast cancer is very controversial. Analyses by various authors of the effect of drug-induced amenorrhea (DIA) on treatment outcome have yielded conflicting results. In order to gain insight

Combined endocrine treatment of elderly postmenopausal patients with metastatic breast cancer. A randomized trial of tamoxifen vs. tamoxifen + aminoglutethimide and hydrocortisone and tamoxifen + fluoxymesterone in women above 65 years of age.

C Rose et al.

Breast cancer research and treatment, 61(2), 103-110 (2000-08-15)

The efficacy of combined endocrine therapy with tamoxifen (TAM), aminoglutethimide (AG), and hydrocortisone (H) or tamoxifen and fluoxymesterone (FLU) was evaluated against treatment with tamoxifen alone in 311 patients above 65 years of age with a first recurrence of a

Combination chemotherapy for metastatic or recurrent carcinoma of the breast--a randomized phase III trial comparing CAF versus VATH versus VATH alternating with CMFVP: Cancer and Leukemia Group B Study 8281.

J Aisner et al.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 13(6), 1443-1452 (1995-06-01)

We sought to compare three doxorubicin-based therapies for metastatic breast cancer for response frequency, time to treatment failure (TTF), and survival. Women with metastatic breast cancer who had measurable disease, required laboratory tests, had received no prior chemotherapy for metastases

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氟甲睾酮

solid (photosensitive)

选择尺寸

关于此项目

主要文件

属性

产品名称

InChI key

InChI

SMILES string

biological source

form

drug control

technique(s)

color

solubility

application(s)

shipped in

storage temp.

Gene Information

说明

Biochem/physiol Actions

安全信息

pictograms

signalword

hcodes

pcodes

Hazard Classifications

存储类别

wgk

flash_point_f

flash_point_c

ppe

法规信息

文件

分析证书(COA)

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