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安全信息

F7751

Sigma-Aldrich

氟甲睾酮

solid (photosensitive)

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别名:
11β,17β-Dihydroxy-9α-fluoro-17α-methyl-4-androsten-3-one, 9α-Fluoro-11β,17β-dihydroxy-17α-methylandrost-4-en-3-one, 9α-Fluoro-11β-hydroxy-17α-methyltestosterone
经验公式（希尔记法）:
C20H29FO3
CAS号:
76-43-7
分子量:
336.44
EC 号:
200-961-8
MDL编号:
MFCD00010480
PubChem化学物质编号:
24894947

生物来源

Porcine pancreas
bovine milk (other parts like skeletal muscle/bile/bone/connective tissue/skin)
microbial (Mycobacterium sp.)

形式

solid (photosensitive)

药品控制

USDEA Schedule III; Home Office Schedule 4.2; regulated under CDSA - not available from Sigma-Aldrich Canada

技术

HPLC: suitable
gas chromatography (GC): suitable

颜色

white

溶解性

H2O: ≤0.5 mg/mL
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 6.4 mg/mL
ethanol: 7.3 mg/mL

应用

forensics and toxicology
veterinary

运输

ambient

储存温度

room temp

SMILES字符串

[H][C@@]12CC[C@](C)(O)[C@@]1(C)C[C@H](O)[C@@]3(F)[C@@]2([H])CCC4=CC(=O)CC[C@]34C

InChI

1S/C20H29FO3/c1-17-8-6-13(22)10-12(17)4-5-15-14-7-9-19(3,24)18(14,2)11-16(23)20(15,17)21/h10,14-16,23-24H,4-9,11H2,1-3H3/t14-,15-,16-,17-,18-,19-,20-/m0/s1

InChI key

YLRFCQOZQXIBAB-RBZZARIASA-N

基因信息

human ... AR(367) , ESR1(2099) , PRLR(5618)

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生化/生理作用

Fluoxymesterone is an androgen and anabolic steroid.

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Toktam Zohoorian-Abootorabi et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 88, 177-191 (2012-01-06)
This study was designed to examine the interaction of two anti-breast cancer drugs, i.e., fluoxymesterone (FLU) and cyclophosphamide (CYC), with human serum albumin (HSA) using different kinds of spectroscopic, zeta potential and molecular modeling techniques under imitated physiological conditions. The
Jeffrey N Miner et al.
Endocrinology, 148(1), 363-373 (2006-10-07)
A number of conditions, including osteoporosis, frailty, and sexual dysfunction in both men and women have been improved using androgens. However, androgens are not widely used for these indications because of the side effects associated with these drugs. We describe
Cornelia Fürstenberger et al.
Toxicological sciences : an official journal of the Society of Toxicology, 126(2), 353-361 (2012-01-26)
Anabolic androgenic steroids (AAS) are testosterone derivatives used either clinically, in elite sports, or for body shaping with the goal to increase muscle size and strength. Clinically developed compounds and nonclinically tested designer steroids often marketed as food supplements are
J E Olson et al.
Cancer, 79(6), 1138-1149 (1997-03-15)
The purpose of this study was to test the role of radiotherapy following total mastectomy, axillary dissection, and adjuvant systemic therapy in the management of operable locally advanced breast carcinoma. After undergoing mastectomy and axillary dissection, 426 patients with locally
C Rose et al.
Breast cancer research and treatment, 61(2), 103-110 (2000-08-15)
The efficacy of combined endocrine therapy with tamoxifen (TAM), aminoglutethimide (AG), and hydrocortisone (H) or tamoxifen and fluoxymesterone (FLU) was evaluated against treatment with tamoxifen alone in 311 patients above 65 years of age with a first recurrence of a
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