F8512
抗-纤维蛋白原 山羊抗
whole antiserum
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Conjugate:
unconjugated
Clone:
polyclonal
Application:
indirect ELISA
quantitative precipitin assay
quantitative precipitin assay
Species reactivity:
human
Citations:
18
Technique(s):
indirect ELISA: 1:10,000
quantitative precipitin assay: 2.0 mg/mL
quantitative precipitin assay: 2.0 mg/mL
Uniprot accession no.:
产品名称
抗-纤维蛋白原 山羊抗, whole antiserum
biological source
goat
conjugate
unconjugated
antibody form
whole antiserum
antibody product type
primary antibodies
clone
polyclonal
contains
15 mM sodium azide
species reactivity
human
technique(s)
indirect ELISA: 1:10,000
quantitative precipitin assay: 2.0 mg/mL
UniProt accession no.
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
General description
纤维蛋白原基因簇由纤维蛋白原α、β和γ链组成。它由人类染色体基因位点4q31.3−4q32.1编码。
纤维蛋白原是一种凝血酶可凝固的可溶性血浆 340 kDa 糖蛋白，由成对的三个亚基（即α、β 、γ）组成 。在保护血管网络免受组织损伤后失血方面，它发挥着至关重要的作用。在三个亚基中，β和γ亚基含有一个N-糖基化位点，该位点被双触角N-聚糖占据。它包含三对二硫键链（即所谓α、β和γ），并进一步折叠成四个结构域：D、E、接头和 A 链的 COOH 末端区域。
Application
山羊源抗纤维蛋白原抗体可用于：
- 人结肠腺癌细胞系中的免疫印迹检测
- 检测血浆中的纤维蛋白原
- 人无血小板血浆（PFP）的免疫测定
抗纤维蛋白原抗体适用于小鼠肝纤维蛋白沉积分析中的免疫染色，以及在夹心ELISA中对抗体进行捕获。 它也适用于间接ELISA（1:10,000稀释）和定量沉淀素测定（浓度为2.0mg/mL）。
Biochem/physiol Actions
纤溶酶可攻击Aα链COOH结构域以产生异质片段X。多轮降解会产生末端消化产物−片段D和E，其为纤维蛋白原的主要球状结构域。该基因的突变会导致多种疾病，包括低纤维蛋白原血症和无纤维蛋白原血症。
通过免疫电泳比较人血浆和纤维蛋白原，研究人员已确定抗血清对纤维蛋白原具有免疫特异性。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、体外或体内治疗用途，或人类或动物任何类型的消费或使用。
Immunogen
人纤维蛋白原
Preparation Note
经处理以去除脂蛋白
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存储类别
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
A quantitative immunoassay for lung cancer biomarker CIZ1b in patient plasma.
Coverley D, et al.
Clinical Biochemistry, 50(6), 336-343 (2017)
Dawn Coverley et al.
Clinical biochemistry, 50(6), 336-343 (2016-11-22)
Non-invasive tests for early detection of lung cancer are an important unmet clinical need. CIZ1b plasma biomarker can discriminate stage 1 lung cancer from within high-risk groups with clinically useful accuracy, with ROC AUCs in excess of 0.9 for two
Targeting the Mitochondrial Chaperone TRAP1 Alleviates Vascular Pathologies in Ischemic Retinopathy.
So-Yeon Kim et al.
Advanced science (Weinheim, Baden-Wurttemberg, Germany), 11(2), e2302776-e2302776 (2023-11-20)
Activation of hypoxia-inducible factor 1α (HIF1α) contributes to blood-retinal barrier (BRB) breakdown and pathological neovascularization responsible for vision loss in ischemic retinal diseases. During disease progression, mitochondrial biology is altered to adapt to the ischemic environment created by initial vascular
Inhibiting host-protein deposition on urinary catheters reduces associated urinary tract infections.
Marissa Jeme Andersen et al.
eLife, 11 (2022-03-30)
Microbial adhesion to medical devices is common for hospital-acquired infections, particularly for urinary catheters. If not properly treated these infections cause complications and exacerbate antimicrobial resistance. Catheter use elicits bladder inflammation, releasing host serum proteins, including fibrinogen (Fg), into the
Platelet adhesion and plasma protein adsorption control of collagen surfaces by He+ ion implantation.
Kurotobi K, et al.
Nucl. Instrum. Methods Phys. Res. Sect. B, 206(6), 532-537 (2003)
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