Merck
CN

F8929

Sigma-Aldrich

氟康唑

≥98% (HPLC), powder

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别名:
2-(2,4-二氟苯基)-1,3-双(1H-1,2,4-三唑-1-基)丙-2-醇
Empirical Formula (Hill Notation):
C13H12F2N6O
CAS号:
分子量:
306.27
MDL编号:
PubChem化学物质编号:
NACRES:
NA.77

质量水平

检测方案

≥98% (HPLC)

形式

powder

溶解性

DMSO: 5 mg/mL

抗生素抗菌谱

fungi

作用机制

enzyme | inhibits

储存温度

room temp

SMILES string

FC1=CC(F)=C(C(CN2N=CN=C2)(O)CN3N=CN=C3)C=C1

InChI

1S/C13H12F2N6O/c14-10-1-2-11(12(15)3-10)13(22,4-20-8-16-6-18-20)5-21-9-17-7-19-21/h1-3,6-9,22H,4-5H2

InChI key

RFHAOTPXVQNOHP-UHFFFAOYSA-N

Gene Information

human ... CYP1A2(1544)

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此商品
PHR11601271700Y0000557
Fluconazole ≥98% (HPLC), powder

Sigma-Aldrich

F8929

氟康唑

Fluconazole Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1160

氟康唑

Fluconazole United States Pharmacopeia (USP) Reference Standard

USP

1271700

氟康唑

Fluconazole European Pharmacopoeia (EP) Reference Standard

Y0000557

氟康唑

form

powder

form

-

form

-

form

-

solubility

DMSO: 5 mg/mL

solubility

-

solubility

-

solubility

-

storage temp.

room temp

storage temp.

2-30°C

storage temp.

-

storage temp.

2-8°C

antibiotic activity spectrum

fungi

antibiotic activity spectrum

-

antibiotic activity spectrum

-

antibiotic activity spectrum

-

mode of action

enzyme | inhibits

mode of action

-

mode of action

-

mode of action

-

一般描述

氟康唑用于治疗中性细胞减少症成人患者的侵袭性假丝酵母菌病(IC)。

应用

氟康唑已用于评估最低抑菌浓度(MIC)-真菌检测。它还被用作植物抗真菌检测的阳性对照。

生化/生理作用

氟康唑是一种抗真菌剂。是真菌细胞色素P-450甾醇C-14α-去甲基化的高选择性抑制剂。氟康唑是一种有效的CYP2C9抑制剂。氟康唑可干扰真菌麦角甾醇合成并下调金属硫蛋白基因。

特点和优势

该化合物是ADME Tox研究的特色产品。点击此处 了解更多ADME Tox的特色产品。了解更多有关用于其他研究领域的生物活性小分子的信息,请访问sigma.com/discover-bsm

象形图

Exclamation markHealth hazard

警示用语:

Danger

危险分类

Acute Tox. 4 Oral - Aquatic Chronic 3 - Lact. - Repr. 1B

储存分类代码

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves


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Posaconazole ≥98% (HPLC)

Sigma-Aldrich

SML2287

泊沙康唑标准液

Posaconazole VETRANAL®, analytical standard

Supelco

32103

泊沙康唑标准液

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BP1175

氟康唑杂质标准品

Amphotericin B solubilized powder, γ-irradiated, BioXtra, suitable for cell culture

Sigma-Aldrich

A9528

两性霉素B,可溶

Maiken Cavling Arendrup et al.
Antimicrobial agents and chemotherapy, 53(4), 1628-1629 (2009-02-04)
The fluconazole MIC distributions for Candida glabrata from testing 34 different clinical isolates and performing 51 tests on a single isolate mirrored each other. Since what is perceived as biological variation in isolates without resistance mechanisms is mainly methodological variation
Screening of selected medicinal plants for their antifungal properties
Aboh MI, et al.
African Journal of Clinical and Experimental Microbiolog, 20(1), 54-59 (2019)
Current antifungal drugs and immunotherapeutic approaches as promising strategies to treatment of fungal diseases
Nami S, et al.
Biomedicine and Pharmacotherapy, 110, 857-868 (2019)
H M H N Bandara et al.
Scientific reports, 10(1), 7769-7769 (2020-05-10)
Microorganisms employ quorum sensing (QS) mechanisms to communicate with each other within microbial ecosystems. Emerging evidence suggests that intraspecies and interspecies QS plays an important role in antimicrobial resistance in microbial communities. However, the relationship between interkingdom QS and antimicrobial
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