F9381
氟米龙
≥98%
别名:
11β,17α-Dihydroxy-9-fluoro-6-methyl-1,4-pregnadiene-3,20-dione
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关于此项目
经验公式（希尔记法）:
C22H29FO4
化学文摘社编号:
分子量:
376.46
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352212
EC Number:
207-041-5
MDL number:
Assay:
≥98%
Quality level:
Quality Level
assay
≥98%
SMILES string
C[C@H]1C[C@H]2[C@@H]3CC[C@](O)(C(C)=O)[C@@]3(C)C[C@H](O)[C@]2(F)[C@@]4(C)C=CC(=O)C=C14
InChI
1S/C22H29FO4/c1-12-9-17-15-6-8-21(27,13(2)24)20(15,4)11-18(26)22(17,23)19(3)7-5-14(25)10-16(12)19/h5,7,10,12,15,17-18,26-27H,6,8-9,11H2,1-4H3/t12-,15-,17-,18-,19-,20-,21-,22-/m0/s1
InChI key
FAOZLTXFLGPHNG-KNAQIMQKSA-N
Gene Information
human ... NR3C1(2908)
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相关类别
Application
- Topical fluorometholone treatment and desiccating stress change inflammatory protein expression in tears.: This research explores the changes in tear protein expression due to topical fluorometholone and environmental stress, offering insights into ocular surface inflammatory responses (Nättinen et al., 2018).
- General Pharmacokinetic Model for Topically Administered Ocular Drug Dosage Forms.: This study provides a pharmacokinetic model applicable to topical ocular medications, including fluorometholone, enhancing understanding of drug dynamics in eye treatments (Deng et al., 2016).
Biochem/physiol Actions
Clinically significant in allergic conjunctivitis and as anti-inflammatory following cataract surgery.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
涉药品监管产品
此项目有
Kensaku Miyake et al.
Journal of cataract and refractive surgery, 37(9), 1581-1588 (2011-08-23)
To compare a topical nonsteroidal antiinflammatory drug (nepafenac 0.1%) and a topical steroidal antiinflammatory drug (fluorometholone 0.1% ) in preventing cystoid macular edema (CME) and blood-aqueous barrier (BAB) disruption after small-incision cataract extraction with foldable intraocular lens (IOL) implantation. Shohzankai
O Van Den Hauwe et al.
Rapid communications in mass spectrometry : RCM, 15(11), 857-861 (2001-05-31)
In this study a new method for the simultaneous confirmation of betamethasone and dexamethasone residues in bovine liver is presented. A Quattro LCZ triple quadrupole mass spectrometer, equipped with an atmospheric pressure ionization (API) source, was coupled to a high
Jun Shimazaki et al.
Ophthalmology, 119(4), 668-673 (2012-01-24)
Endothelial rejection remains a major cause of graft failure after penetrating keratoplasty (PKP). Topical corticosteroids are the gold standard for preventing rejection; however, protocols for corticosteroid treatment have been diverse. The aim of the present study was to examine the
Deniz Hos et al.
Archives of ophthalmology (Chicago, Ill. : 1960), 129(4), 445-452 (2011-04-13)
To analyze whether topical application of corticosteroids inhibits inflammatory corneal lymphangiogenesis and to study the potential underlying antilymphangiogenic mechanisms. Inflammatory corneal neovascularization was induced by suture placement, and the corneas were then treated with topical fluorometholone, prednisolone acetate, or dexamethasone
Lei Zhu et al.
Molecular vision, 18, 1803-1812 (2012-07-21)
To evaluate the effect of the topical steroid, fluorometholone, and the non-steroidal anti-inflammatory drugs (NSAIDs), nepafenac and ketorolac, on inflammatory cytokine expression of the ocular surface in the botulium toxin B-induced murine dry eye model. Topical artificial tears (0.5% carboxymethylcellulose
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| F9381-100MG | 04061835544943 |
| F9381-500MG | 04061835544950 |
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