F9397
氟他胺
Non-steroidal anti-androgen drug
别名:
2-甲基-N-[4-硝基-3-（三氟甲基）苯基]丙酰胺
Product Name
氟他胺,
质量水平
创始人
Schering Plough
SMILES字符串
CC(C)C(=O)Nc1ccc(c(c1)C(F)(F)F)[N+]([O-])=O
InChI
1S/C11H11F3N2O3/c1-6(2)10(17)15-7-3-4-9(16(18)19)8(5-7)11(12,13)14/h3-6H,1-2H3,(H,15,17)
InChI key
MKXKFYHWDHIYRV-UHFFFAOYSA-N
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相关类别
应用
氟他胺已被用于考察睾丸素对胶质细胞源性神经营养因子（Gdnf）mRNA的体外生产的影响。它还被用于研究氟他胺对肛门生殖器距离和乳头保留的影响。
生化/生理作用
氟他胺是一种非甾体抗雄激素药。它包括硝基芳香结构。氟他胺是睾丸素和二氢睾丸素受体的强效竞争剂。它是一种强效的肝毒素。
特点和优势
该化合物由Schering Plough开发。要浏览其他药物开发化合物和批准的药物/候选药物列表，单击此处。
警示用语：
Warning
危险分类
Acute Tox. 4 Oral - Aquatic Chronic 2 - Carc. 2 - Repr. 2 - STOT RE 2
靶器官
Liver
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
Flutamide-induced hepatotoxicity: ethical and scientific issues
Giorgetti R, et al.
European Review for Medical and Pharmacological Sciences, 21(1 Suppl), 69-77 (2017)
Anthony Schroeder et al.
General and comparative endocrinology, 281, 7-16 (2019-05-07)
Sex steroids are involved in sex determination in almost all vertebrates, including species with temperature-dependent sex determination (TSD). It is well established that aromatase and estrogens are involved in ovary determination in TSD species. In contrast, the role of non-aromatizable
Combined exposure to anti-androgens exacerbates disruption of sexual differentiation in the rat
Hass U, et al.
Environmental Health Perspectives, 115(Suppl 1), 122-128 (2007)
N A Spry et al.
Prostate cancer and prostatic diseases, 16(1), 67-72 (2012-08-22)
To examine changes to whole body and regional lean mass (LM) and fat mass (FM) over 33 months of intermittent androgen suppression therapy (IAST). Phase II cohort study of 72 prostate cancer patients without metastatic bone disease. Patients received flutamide
Shuchen Gu et al.
Cellular signalling, 25(1), 66-73 (2013-01-15)
Actin cytoskeleton reorganization initiated by testosterone conjugates through activation of membrane androgen receptors (mAR) has recently been reported in colon tumor cells. This mAR-induced actin reorganization was recognized as a critical initial event, controlling apoptosis and inhibiting cell migration. The
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