F9397
氟他胺
Non-steroidal anti-androgen drug
别名:
2-甲基-N-[4-硝基-3-（三氟甲基）苯基]丙酰胺
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关于此项目
经验公式（希尔记法）:
C11H11F3N2O3
化学文摘社编号:
分子量:
276.21
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
51111800
EC Number:
236-341-9
MDL number:
Quality level:
产品名称
氟他胺,
InChI
1S/C11H11F3N2O3/c1-6(2)10(17)15-7-3-4-9(16(18)19)8(5-7)11(12,13)14/h3-6H,1-2H3,(H,15,17)
InChI key
MKXKFYHWDHIYRV-UHFFFAOYSA-N
SMILES string
CC(C)C(=O)Nc1ccc(c(c1)C(F)(F)F)[N+]([O-])=O
originator
Schering Plough
Quality Level
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相关类别
Application
氟他胺已被用于考察睾丸素对胶质细胞源性神经营养因子（Gdnf）mRNA的体外生产的影响。它还被用于研究氟他胺对肛门生殖器距离和乳头保留的影响。
Biochem/physiol Actions
氟他胺是一种非甾体抗雄激素药。它包括硝基芳香结构。氟他胺是睾丸素和二氢睾丸素受体的强效竞争剂。它是一种强效的肝毒素。
Features and Benefits
该化合物由Schering Plough开发。要浏览其他药物开发化合物和批准的药物/候选药物列表，单击此处。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Chronic 2 - Carc. 2 - Repr. 2 - STOT RE 2
target_organs
Liver
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
N A Spry et al.
Prostate cancer and prostatic diseases, 16(1), 67-72 (2012-08-22)
To examine changes to whole body and regional lean mass (LM) and fat mass (FM) over 33 months of intermittent androgen suppression therapy (IAST). Phase II cohort study of 72 prostate cancer patients without metastatic bone disease. Patients received flutamide
Shuchen Gu et al.
Cellular signalling, 25(1), 66-73 (2013-01-15)
Actin cytoskeleton reorganization initiated by testosterone conjugates through activation of membrane androgen receptors (mAR) has recently been reported in colon tumor cells. This mAR-induced actin reorganization was recognized as a critical initial event, controlling apoptosis and inhibiting cell migration. The
Flutamide-induced hepatotoxicity: ethical and scientific issues
Giorgetti R, et al.
European Review for Medical and Pharmacological Sciences, 21(1 Suppl), 69-77 (2017)
Combined exposure to anti-androgens exacerbates disruption of sexual differentiation in the rat
Hass U, et al.
Environmental Health Perspectives, 115(Suppl 1), 122-128 (2007)
Santiago Rolon et al.
Physiological reports, 9(1), e14663-e14663 (2021-01-05)
Hypoxia is common with preterm birth and may lead to long-term effects on adult pancreatic endocrine function and insulin sensitivity. This phenomenon may be sexually dimorphic due to the hypoxia-induced augmentation of the neonatal androgen surge in male newborns. We
相关内容
Product Information Sheet
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