F9554
Anti-Fatty Acid Synthase antibody produced in rabbit
1 mg/mL, affinity isolated antibody, buffered aqueous solution
别名:
Anti-FAS, Anti-FASN
产品名称
Anti-Fatty Acid Synthase antibody produced in rabbit, 1 mg/mL, affinity isolated antibody, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 270 kDa
species reactivity
mouse, rat, human (predicted)
concentration
1 mg/mL
technique(s)
western blot: 0.5-1 μg/mL using lysates of mouse myoblast C2 cells
western blot: 0.5-1 μg/mL using lysates of rat hepatocytoma FAO cells
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... FASN(2194)
mouse ... Fasn(14104)
rat ... Fasn(50671)
Application
Anti-Fatty Acid Synthase antibody is suitable for western blot analysis at a concentration of 0.5-1μg/mL using lysates of mouse myoblast C2 cells and rat hepatocytoma FAO cells.
Fatty acid synthase antibody produced in rabbit has been used in immunohistochemistry and western blot analysis.
Biochem/physiol Actions
FAS plays an essential role during embryogenesis and energy homeostasis in adult animals. It also acts as the carbon source for fatty acid synthesis. It has been shown to be overexpressed in various types of human cancer, including prostate, breast, ovary and others. FASN is a multifunctional protein, mainly involved in catalyzing the synthesis of palmitate from acetyl-CoA and malonyl CoA, in the presence of NADPH.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Fatty Acid Synthase encodes an enzyme that is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids.
Fatty acid synthase (FAS, FASN) is encoded by the gene mapped to human chromosome 17q25.3. In mammals, it is composed of two identical multifunctional polypeptides, in which three catalytic domains in the N-terminal section (β-ketoacyl synthase, malonyl/acetyl tansferase, and dehydrase) are separated by a core region of about 600 residues from four C-terminal domains (enoyl reductase, β-ketoacyl reductase, acyl carrier protein, and thioesterase).
Immunogen
synthetic peptide corresponding to amino acids 1982-1999 of mouse fatty acid synthase, conjugated to KLH via an N-terminal added cysteine residue. The immunizing peptide is conserved in rat and differs from the human sequence by three amino acids.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
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存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
此项目有
Bobby Guillory et al.
Aging cell, 17(1) (2017-10-13)
Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide. NAFLD usually begins as low-grade hepatic steatosis which further progresses in an age-dependent manner to nonalcoholic steatohepatitis (NASH), fibrosis, cirrhosis, and hepatocellular carcinoma in some patients. Ghrelin is
Henriette Kirchner et al.
Molecular metabolism, 5(3), 171-183 (2016-03-16)
Epigenetic modifications contribute to the etiology of type 2 diabetes. We performed genome-wide methylome and transcriptome analysis in liver from severely obese men with or without type 2 diabetes and non-obese men to discover aberrant pathways underlying the development of
C Rufo et al.
The Journal of biological chemistry, 276(24), 21969-21975 (2001-03-30)
Refeeding carbohydrate to fasted rats induces the transcription of genes encoding enzymes of fatty acid biosynthesis, e.g. fatty-acid synthase (FAS). Part of this transcriptional induction is mediated by insulin. An insulin response element has been described for the fatty-acid synthase
Javier A Menendez et al.
Proceedings of the National Academy of Sciences of the United States of America, 101(29), 10715-10720 (2004-07-06)
Fatty acid synthase (FAS) activity is a potential therapeutic target to treat cancer and obesity. Here, we have identified a molecular link between FAS and HER2 (erbB-2) oncogene, a marker for poor prognosis that is overexpressed in 30% of breast
DaoHai Zhang et al.
Molecular & cellular proteomics : MCP, 4(11), 1686-1696 (2005-07-29)
The receptor tyrosine kinase ErbB2 (HER-2/neu) is overexpressed in up to 30% of breast cancers and is associated with poor prognosis and an increased likelihood of metastasis especially in node-positive tumors. In this proteomic study, to identify the proteins that
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