F9677
非洛地平
L-type calcium channel blocker, solid
别名:
4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylic acid ethyl methyl ester, Plendil
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关于此项目
经验公式（希尔记法）:
C18H19NO4Cl2
CAS Number:
分子量:
384.25
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
Product Name
非洛地平, solid
表单
solid
质量水平
溶解性
DMSO: 20 mg/mL
H2O: insoluble
创始人
AstraZeneca
SMILES字符串
CCOC(=O)C1=C(C)NC(C)=C(C1c2cccc(Cl)c2Cl)C(=O)OC
InChI
1S/C18H19Cl2NO4/c1-5-25-18(23)14-10(3)21-9(2)13(17(22)24-4)15(14)11-7-6-8-12(19)16(11)20/h6-8,15,21H,5H2,1-4H3
InChI key
RZTAMFZIAATZDJ-UHFFFAOYSA-N
基因信息
human ... CACNA1C(775), CACNA1D(776), CACNA1F(778), CACNA1S(779), CACNA2D1(781), NR3C2(4306)
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相关类别
一般描述
Felodipine is a dihydropyridine derivative. It has diuretic properties. Felodipine has high vascular selectivity. It is used to treat hypertension. Felodipine regulates chronic stable angina.
生化/生理作用
L-type calcium channel blocker
特点和优势
This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
警示用语：
Warning
危险分类
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 2 - STOT RE 2 Inhalation
储存分类代码
11 - Combustible Solids
WGK
WGK 3
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Sofia A Papadimitriou et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 82(1), 175-186 (2012-06-27)
In the present study, the efficiency of PVP/PEG200 mixtures as appropriate carries for the preparation of solid dispersions by melt mixing was evaluated. Felodipine (FELO) was used as a poorly water soluble model drug. The effect of several melt mixing
Meyler's Side Effects of Cardiovascular Drugs (2009)
Effects of felodipine on haemodynamics and exercise capacity in patients with angina pectoris.
Sheridan JV, et al.
British Journal of Clinical Pharmacology, 23(4), 391-396 (1987)
Sheng Qi et al.
Pharmaceutical research, 28(9), 2311-2326 (2011-05-25)
To characterise phase separations in aged hot-melt-extruded solid dispersions at a micron to submicron scale. Hot-melt-extruded felodipine and Eudragit® E PO systems at a range of compositions were studied after a standard period of aging to allow phase separation to
Morten Schmidt et al.
European journal of clinical investigation, 42(3), 266-274 (2011-08-13)
The CYP3A4 inhibition by calcium channel blockers (CCBs) may attenuate the effectiveness of clopidogrel. Using time-varying drug exposure ascertainment, we examined whether CCB use modified the association between clopidogrel use and major adverse cardiovascular events (MACE) after coronary stent implantation.
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