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F9677

非洛地平

Name: 非洛地平
Brand: SIGMA

L-type calcium channel blocker, solid

别名:

4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylic acid ethyl methyl ester, Plendil

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关于此项目

经验公式（希尔记法）:

C₁₈H₁₉NO₄Cl₂

化学文摘社编号:

72509-76-3

分子量:

384.25

UNSPSC Code:

12352200

PubChem Substance ID:

24278449

NACRES:

NA.77

MDL number:

MFCD00868316

Form:

solid

Quality level:

200

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产品名称

非洛地平, solid

form

solid

Quality Level

200

solubility

DMSO: 20 mg/mL, H₂O: insoluble

originator

AstraZeneca

SMILES string

CCOC(=O)C1=C(C)NC(C)=C(C1c2cccc(Cl)c2Cl)C(=O)OC

InChI

1S/C18H19Cl2NO4/c1-5-25-18(23)14-10(3)21-9(2)13(17(22)24-4)15(14)11-7-6-8-12(19)16(11)20/h6-8,15,21H,5H2,1-4H3

InChI key

RZTAMFZIAATZDJ-UHFFFAOYSA-N

Gene Information

human ... CACNA1C(775), CACNA1D(776), CACNA1F(778), CACNA1S(779), CACNA2D1(781), NR3C2(4306)

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General description

Felodipine is a dihydropyridine derivative. It has diuretic properties. Felodipine has high vascular selectivity. It is used to treat hypertension. Felodipine regulates chronic stable angina.

Biochem/physiol Actions

L-type calcium channel blocker

Features and Benefits

This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

GHS08,GHS07,GHS09

signalword

Warning

hcodes

H302,H361d,H373,H410

pcodes

P202 - P260 - P264 - P273 - P301 + P312 - P308 + P313

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 2 - STOT RE 2 Inhalation

存储类别

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

0000509688

0000496158

0000415775

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Effects of felodipine on haemodynamics and exercise capacity in patients with angina pectoris.

Sheridan JV, et al.

British Journal of Clinical Pharmacology, 23(4), 391-396 (1987)

Optimizing the ability of PVP/PEG mixtures to be used as appropriate carriers for the preparation of drug solid dispersions by melt mixing technique using artificial neural networks: I.

Sofia A Papadimitriou et al.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 82(1), 175-186 (2012-06-27)

In the present study, the efficiency of PVP/PEG200 mixtures as appropriate carries for the preparation of solid dispersions by melt mixing was evaluated. Felodipine (FELO) was used as a poorly water soluble model drug. The effect of several melt mixing

Meyler's Side Effects of Cardiovascular Drugs (2009)

Compositional analysis of low quantities of phase separation in hot-melt-extruded solid dispersions: a combined atomic force microscopy, photothermal fourier-transform infrared microspectroscopy, and localised thermal analysis approach.

Sheng Qi et al.

Pharmaceutical research, 28(9), 2311-2326 (2011-05-25)

To characterise phase separations in aged hot-melt-extruded solid dispersions at a micron to submicron scale. Hot-melt-extruded felodipine and Eudragit® E PO systems at a range of compositions were studied after a standard period of aging to allow phase separation to

Effect of felodipine with irbesartan or metoprolol on sexual function and oxidative stress in women with essential hypertension.

Ruixin Ma et al.

Journal of hypertension, 30(1), 210-216 (2011-12-03)

To evaluate the impact of felodipine with irbesartan on sexual function compared with felodipine with metoprolol in hypertensive women. This was a prospective, randomized, parallel, active-controlled, open-label study (ClinicalTrials.org: NCT01238705) in 160 women (18-60 years) with mild or moderate hypertension

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全球贸易项目编号

货号	GTIN
F9677-25MG	04061832961668
F9677-5MG	04061832961675

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