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F9677

非洛地平

Name: 非洛地平
Brand: SIGMA

L-type calcium channel blocker, solid

别名:

4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylic acid ethyl methyl ester, Plendil

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关于此项目

经验公式（希尔记法）:

C₁₈H₁₉NO₄Cl₂

化学文摘社编号:

72509-76-3

分子量:

384.25

UNSPSC Code:

12352200

PubChem Substance ID:

24278449

NACRES:

NA.77

MDL number:

MFCD00868316

Form:

solid

Quality level:

200

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属性

产品名称

非洛地平, solid

form

solid

Quality Level

200

solubility

DMSO: 20 mg/mL, H₂O: insoluble

originator

AstraZeneca

SMILES string

CCOC(=O)C1=C(C)NC(C)=C(C1c2cccc(Cl)c2Cl)C(=O)OC

InChI

1S/C18H19Cl2NO4/c1-5-25-18(23)14-10(3)21-9(2)13(17(22)24-4)15(14)11-7-6-8-12(19)16(11)20/h6-8,15,21H,5H2,1-4H3

InChI key

RZTAMFZIAATZDJ-UHFFFAOYSA-N

Gene Information

human ... CACNA1C(775), CACNA1D(776), CACNA1F(778), CACNA1S(779), CACNA2D1(781), NR3C2(4306)

说明

General description

Felodipine is a dihydropyridine derivative. It has diuretic properties. Felodipine has high vascular selectivity. It is used to treat hypertension. Felodipine regulates chronic stable angina.

Biochem/physiol Actions

L-type calcium channel blocker

Features and Benefits

This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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pictograms

GHS08,GHS07,GHS09

signalword

Warning

hcodes

H302,H361d,H373,H410

pcodes

P202 - P260 - P264 - P273 - P301 + P312 - P308 + P313

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 2 - STOT RE 2 Inhalation

存储类别

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Effects of felodipine on haemodynamics and exercise capacity in patients with angina pectoris.

Sheridan JV, et al.

British Journal of Clinical Pharmacology, 23(4), 391-396 (1987)

Optimizing the ability of PVP/PEG mixtures to be used as appropriate carriers for the preparation of drug solid dispersions by melt mixing technique using artificial neural networks: I.

Sofia A Papadimitriou et al.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 82(1), 175-186 (2012-06-27)

In the present study, the efficiency of PVP/PEG200 mixtures as appropriate carries for the preparation of solid dispersions by melt mixing was evaluated. Felodipine (FELO) was used as a poorly water soluble model drug. The effect of several melt mixing

Meyler's Side Effects of Cardiovascular Drugs (2009)

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全球贸易项目编号

货号	GTIN
F9677-25MG	04061832961668
F9677-5MG	04061832961675