FSL-LE^a(tri)

All FSL constructs disperse in biocompatible media and spontaneously and stably incorporate into cell membranes. Cells modified with KODE constructs are known as kodecytes and usually maintain their normal vitality and functionality.

FSL-Le^a(tri) has been specifically designed to create live cells (kodecytes) expressing blood group Le^a antigens but can also be used to modify other hydrophobic surfaces including fixed cells, virions, and solid phase surfaces. This product can be used to attach reproducible and controlled levels of blood group Le^a antigens to erythrocytes. These kodecytes will react with most anti-Le^a blood grouping reagents including polyclonal reagents. Le^a-kodecytes will also react with monoclonal anti-Le^b as these reagents also cross-react with Le^a.

All FSL constructs disperse in biocompatible media and spontaneously and stably incorporate into cell membranes. FSL-Le^a(tri) has been specifically designed to create live cells (kodecytes) expressing blood group Le^a antigens but can also be used to modify other hydrophobic surfaces including fixed cells, virions, and solid phase surfaces.

FSL-Le^a(tri) is a KODE^™ technology construct designed to label hydrophobic surfaces including living cells with Lewis blood group Le^a trisaccharide. All KODE FSL constructs consist of three essential designable features: a functional component (F), a spacer (S), and a diacyl lipid (L). FSL-Le^a(tri) is comprised of the Lewis blood group Le^a trisaccharide Galβ(Fucα4)GlcNAcβ representing F, conjugated via an O(CH₂)₃NH spacer (SA1) to an activated adipate derivative of dioleoyl­phos­pha­tidyl­ethanolamine (L1).

KODE Constructs are supplied by KODE Biotech Materials Limited under license from KODE Biotech Limited.

KODE is a trademark of KODE Biotech Ltd.