F9803
FTI-277 三氟乙酸盐
≥95% (HPLC), film
别名:
N-[4-[2(R)-氨基-3-巯基丙基]氨基-2-苯基苯甲酰基]蛋氨酸甲酯 三氟乙酸盐
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关于此项目
经验公式（希尔记法）:
C22H29N3O3S2 · xC2HF3O2
化学文摘社编号:
分子量:
447.61 (free base basis)
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
51111800
MDL number:
产品名称
FTI-277 三氟乙酸盐, ≥95% (HPLC), film
InChI key
GJEFFRDWFVSCOJ-PXPMWPIZSA-N
SMILES string
OC(=O)C(F)(F)F.COC(=O)[C@H](CCSC)NC(=O)c1ccc(NC[C@@H](N)CS)cc1-c2ccccc2
InChI
1S/C22H29N3O3S2.C2HF3O2/c1-28-22(27)20(10-11-30-2)25-21(26)18-9-8-17(24-13-16(23)14-29)12-19(18)15-6-4-3-5-7-15;3-2(4,5)1(6)7/h3-9,12,16,20,24,29H,10-11,13-14,23H2,1-2H3,(H,25,26);(H,6,7)/t16-,20+;/m1./s1
assay
≥95% (HPLC)
form
film
storage condition
desiccated
solubility
H2O: ≥2 mg/mL
shipped in
dry ice
storage temp.
−70°C
Quality Level
相关类别
Application
法呢基转移酶抑制剂277（FTI-277）已被用于
- 在乳腺癌细胞系中抑制蛋白法呢基化。
- 骨髓分离的成人多系诱导细胞（MIAMI）中。
- 在与带有SV40基因细胞（COS-7）的起源中抑制CV-1中的法呢基转移酶。
Biochem/physiol Actions
可拮抗H和K-Ras致癌信号的强效（pM/nM）Ras CAAX拟肽。 法呢基转移酶（Ftase）抑制剂IC50 = 50 nM。
法呢基转移酶抑制剂277（FTI-277）可介导多发性骨髓瘤的细胞凋亡，并被认为是一种潜在的治疗剂。
Packaging
极易吸湿材料，与脱氧的MeOH一起包装在干燥的房间中，并抽走溶剂。与干燥剂一起储存。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Daisuke Tsuji et al.
Biochemical and biophysical research communications, 556, 93-98 (2021-04-13)
Sepsis remains a leading cause of mortality in critically ill patients and is characterized by multi-organ dysfunction. Mitochondrial damage has been proposed to be involved in the pathophysiology of sepsis. In addition to metabolic impairments resulting from mitochondrial dysfunction, mitochondrial
Endothelial protective genes induced by statin is mimicked by FTI-277 and GGTI-298 drug combination-mediated ERK5 activation
Chu UB, et al.
Biochimica et Biophysica Acta, 1850(7), 1415-1425 (2015)
The farnesyl transferase inhibitor, FTI-277, inhibits growth and induces apoptosis in drug-resistant myeloma tumor cells
Bolick SCE, et al.
Leukemia, 17(2), 451-457 (2003)
Progerin expression disrupts critical adult stem cell functions involved in tissue repair
Pacheco LM, et al.
Aging (Albany. NY.), 6(12), 1049-1063 (2014)
Bingchen Han et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 30(2), 672-687 (2021-07-19)
Triple-negative breast cancer (TNBC) has a high propensity for organ-specific metastasis. However, the underlying mechanisms are not well understood. Here we show that the primary TNBC tumor-derived C-X-C motif chemokines 1/2/8 (CXCL1/2/8) stimulate lung-resident fibroblasts to produce the C-C motif
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