F9813
氟达拉滨
别名:
2-Fluoro-9-(5-O-phosphono-β-D-arabinofuranosyl)-9H-purin-6-amine
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关于此项目
经验公式（希尔记法）:
C10H13FN5O7P
化学文摘社编号:
分子量:
365.21
MDL number:
UNSPSC Code:
51102829
NACRES:
NA.85
form
powder
Quality Segment
color
white
solubility
DMSO: soluble
antibiotic activity spectrum
neoplastics
mode of action
DNA synthesis | interferes
storage temp.
−20°C
SMILES string
Fc1nc2[n](cnc2c(n1)[N+H3])C3OC(C(C3O)O)CO[P](=O)([O-])O
InChI
1S/C10H13FN5O7P/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(18)5(17)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,17-18H,1H2,(H2,12,14,15)(H2,19,20,21)
InChI key
GIUYCYHIANZCFB-UHFFFAOYSA-N
General description
Fludarabine is a purine analog included in the category of DNA-damaging drugs with well-known efficacy in B-cell chronic lymphocytic leukemia (B-CLL).
Application
- Characterization of Chemical Interactions between Clinical Drugs and the Oral Bacterium, Corynebacterium matruchotii, via Bioactivity-HiTES.: This study explores the interactions of clinical drugs like Fludarabine phosphate with Corynebacterium matruchotii, highlighting potential impacts on oral microbiota and implications for drug efficacy and safety (Lee DY et al., 2024).
- Cocktail of lipophilic and hydrophilic chemotherapeutics in high-load core@shell nanocarriers to treat pancreatic tumours.: Investigates the efficacy of a combination of Fludarabine phosphate with other chemotherapeutics delivered via nanocarriers, aiming to enhance treatment outcomes for pancreatic cancer by improving drug delivery to the tumor site (Rudolph D et al., 2024).
- Macrophage neogenin deficiency exacerbates myocardial remodeling and inflammation after acute myocardial infarction through JAK1-STAT1 signaling.: This research demonstrates the role of Fludarabine phosphate in modulating inflammation and cardiac repair post-myocardial infarction, offering insights into its potential therapeutic benefits beyond oncology (Zhang J et al., 2023).
- SLC25A51 promotes tumor growth through sustaining mitochondria acetylation homeostasis and proline biogenesis.: Discusses the cellular mechanisms by which Fludarabine phosphate may influence metabolic pathways in cancer cells, highlighting its potential to disrupt tumor metabolism and promote cancer cell death (Li Y et al., 2023).
- CD19-Targeting CAR T Cells for Myositis and Interstitial Lung Disease Associated With Antisynthetase Syndrome.: Reviews the use of Fludarabine phosphate in preconditioning regimens for CAR T-cell therapy, emphasizing its role in enhancing the efficacy of immunotherapy in treating autoimmune disorders (Pecher AC et al., 2023).
Biochem/physiol Actions
Fludarabine represses DNA replication and suppresses the nucleotide metabolism by inhibiting the enzyme ribonucleotide reductase.
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signalword
Warning
hcodes
Hazard Classifications
Muta. 2 - Repr. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable