G0903
γ-Glu-Cys
≥80% (HPLC), suitable for ligand binding assays
别名:
γ-L-谷氨酰基-L半胱氨酸, 去甘氨酸-谷胱甘肽的还原形式
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关于此项目
经验公式（希尔记法）:
C8H14N2O5S
化学文摘社编号:
分子量:
250.27
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.26
MDL number:
产品名称
γ-Glu-Cys, ≥80% (HPLC)
SMILES string
N[C@@H](CCC(=O)N[C@@H](CS)C(O)=O)C(O)=O
InChI
1S/C8H14N2O5S/c9-4(7(12)13)1-2-6(11)10-5(3-16)8(14)15/h4-5,16H,1-3,9H2,(H,10,11)(H,12,13)(H,14,15)/t4-,5-/m0/s1
InChI key
RITKHVBHSGLULN-WHFBIAKZSA-N
assay
≥80% (HPLC)
form
powder
composition
Peptide content, ≥60% elemental analysis
technique(s)
ligand binding assay: suitable
color
white to off-white
storage temp.
−20°C
Quality Level
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Application
γ-Glu-Cys可用于研究谷胱甘肽合成酶的活性位点和动力学。它也被用于从拟南芥 组织中提取和量化低分子量硫醇。
Biochem/physiol Actions
γ-L-谷氨酰基-L-半胱氨酸（γ-Glu-Cys）是用于通过谷胱甘肽合成酶生物合成L-谷胱甘肽的底物。γ-Glu-Cys通过裂解谷胱甘肽的Cys-Gly肽键而产生。它对植物螯合素的形成也是必需的，植物螯合素是富含半胱氨酸的硫醇反应性肽。
Physical form
从0.1％TFA中冻干获得。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Runa Njålsson et al.
Human genetics, 116(5), 384-389 (2005-02-18)
Glutathione synthetase (GS) deficiency is a rare autosomal recessive disorder. The clinical phenotype varies widely, and nearly 30 different mutations in the GSS gene have been identified. In the present study, genotype, enzyme activity, metabolite levels and clinical phenotype were
Hemantaranjan, A.
Advances In Plant Physiology (2012)
Jan Stout et al.
Journal of molecular biology, 416(4), 486-494 (2012-01-10)
Glutathione is an intracellular redox-active tripeptide thiol with a central role in cellular physiology across all kingdoms of life. Glutathione biosynthesis has been traditionally viewed as a conserved process relying on the sequential activity of two separate ligases, but recently
Chava B Pocernich et al.
Biochimica et biophysica acta, 1822(5), 625-630 (2011-10-22)
Oxidative stress has been associated with the onset and progression of mild cognitive impairment (MCI) and Alzheimer disease (AD). AD and MCI brain and plasma display extensive oxidative stress as indexed by protein oxidation, lipid peroxidation, free radical formation, DNA
Quantification of Low Molecular Weight Thiols in Arabidopsis
Ziqing Miao
Bio-protocol, 6(1) (2016)
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