G0903
γ-Glu-Cys
≥80% (HPLC), suitable for ligand binding assays
别名:
γ-L-谷氨酰基-L半胱氨酸, 去甘氨酸-谷胱甘肽的还原形式
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关于此项目
经验公式（希尔记法）:
C8H14N2O5S
化学文摘社编号:
分子量:
250.27
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.26
MDL number:
产品名称
γ-Glu-Cys, ≥80% (HPLC)
SMILES string
N[C@@H](CCC(=O)N[C@@H](CS)C(O)=O)C(O)=O
InChI
1S/C8H14N2O5S/c9-4(7(12)13)1-2-6(11)10-5(3-16)8(14)15/h4-5,16H,1-3,9H2,(H,10,11)(H,12,13)(H,14,15)/t4-,5-/m0/s1
InChI key
RITKHVBHSGLULN-WHFBIAKZSA-N
assay
≥80% (HPLC)
form
powder
composition
Peptide content, ≥60% elemental analysis
technique(s)
ligand binding assay: suitable
color
white to off-white
storage temp.
−20°C
Quality Level
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Application
γ-Glu-Cys可用于研究谷胱甘肽合成酶的活性位点和动力学。它也被用于从拟南芥 组织中提取和量化低分子量硫醇。
Biochem/physiol Actions
γ-L-谷氨酰基-L-半胱氨酸（γ-Glu-Cys）是用于通过谷胱甘肽合成酶生物合成L-谷胱甘肽的底物。γ-Glu-Cys通过裂解谷胱甘肽的Cys-Gly肽键而产生。它对植物螯合素的形成也是必需的，植物螯合素是富含半胱氨酸的硫醇反应性肽。
Physical form
从0.1％TFA中冻干获得。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
T Hara et al.
Protein engineering, 8(7), 711-716 (1995-07-01)
Lys18, Arg86, Asn283, Ser286, Thr288 and Glu292 of glutathione synthetase from Escherichia coli B are presumed to be highly concerned with the substrate, gamma-L-glutamyl-L-cysteine (gamma-Glu-Cys), binding by X-ray crystallography and affinity labeling studies. Using site-directed mutagenesis, we investigated functional roles
Helmut Schweikl et al.
Dental materials : official publication of the Academy of Dental Materials, 37(1), 175-190 (2020-12-12)
The release of inflammatory cytokines from antigen-stimulated cells of the immune system is inhibited by resin monomers such as 2-hydroxyethyl methacrylate (HEMA). Although the formation of oxidative stress in cells exposed to HEMA is firmly established, the mechanism behind the
H Yamaguchi et al.
Journal of molecular biology, 229(4), 1083-1100 (1993-02-20)
Glutathione synthetase (gamma-L-glutamyl-L-cysteine: glycine ligase (ADP-forming) EC 6.3.2.3: GSHase) catalyzes the synthesis of glutathione from gamma-L-glutamyl-L-cysteine and Gly in the presence of ATP. The enzyme from Escherichia coli is a tetramer with four identical subunits of 316 amino acid residues.
Runa Njålsson et al.
Human genetics, 116(5), 384-389 (2005-02-18)
Glutathione synthetase (GS) deficiency is a rare autosomal recessive disorder. The clinical phenotype varies widely, and nearly 30 different mutations in the GSS gene have been identified. In the present study, genotype, enzyme activity, metabolite levels and clinical phenotype were
Hemantaranjan, A.
Advances In Plant Physiology (2012)
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