G0923
GBF1抑制剂Golgicide A
≥98% (HPLC)
别名:
6,8-二氟-4-吡啶-3-基-3a,4,5,9b-四氢-3H-环戊[c]喹啉, CID 25113626, GCA
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关于此项目
经验公式（希尔记法）:
C17H14F2N2
化学文摘社编号:
分子量:
284.30
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
产品名称
GBF1抑制剂Golgicide A, ≥98% (HPLC)
Quality Level
SMILES string
Fc1cc(F)c2NC([C@@H]3CC=C[C@@H]3c2c1)c4cccnc4
InChI
1S/C17H14F2N2/c18-11-7-14-12-4-1-5-13(12)16(10-3-2-6-20-9-10)21-17(14)15(19)8-11/h1-4,6-9,12-13,16,21H,5H2/t12-,13+,16?/m0/s1
InChI key
NJZHEQOUHLZCOX-FTLRAWMYSA-N
assay
≥98% (HPLC)
form
solid
solubility
DMSO: >10 mg/mL
storage temp.
room temp
相关类别
Application
杀真菌剂 A 可用作逆转录分析的抑制剂，并被用作 HeLa 细胞中高尔基体特异性布雷菲德菌素 A 抗鸟嘌呤核苷酸交换因子 1 蛋白（GBF1）的抑制剂。
Biochem/physiol Actions
Golgicide A 是一种有效的、高特异性的、可逆的顺式高尔基 体 ArfGEF GBF1 抑制剂。Arf 蛋白是介导小泡运输的小鸟苷三磷酸酶（GTPase）Ras 超家族的成员。Golgicide A 在 Arf1 和 GBF1 Sec7 结构域之间形成的界面裂缝内结合。Golgicide A 是一种独特而强大的工具，可用于进一步阐明高尔基体内组装和运输的机制，而 Dynasore 可用于研究动力蛋白介导的网格蛋白涂层形成动力学。
Golgicide A 是一种有效的、高特异性的、可逆的顺式高尔基体 ArfGEF GBF1 抑制剂。
Features and Benefits
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signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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