G1001
D -谷氨酸
≥99% (TLC), suitable for ligand binding assays
别名:
(R)-2-Aminoglutaric acid, (R)-2-氨基戊二酸, D-Glu, R-(-)-1-氨基丙烷-1,3-二羧酸
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关于此项目
线性分子式:
HO2CCH2CH2CH(NH2)CO2H
化学文摘社编号:
分子量:
147.13
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352209
EC Number:
230-000-8
MDL number:
Beilstein/REAXYS Number:
1723800
产品名称
D -谷氨酸, ≥99% (TLC)
InChI
1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1
InChI key
WHUUTDBJXJRKMK-GSVOUGTGSA-N
SMILES string
N[C@H](CCC(O)=O)C(O)=O
assay
≥99% (TLC)
form
powder
technique(s)
ligand binding assay: suitable
color
white to off-white
mp
200-202 °C (subl.) (lit.)
Quality Level
Gene Information
human ... CCR2(1231)
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Application
D-谷氨酸适用于GR酶（谷氨酸消旋酶）及其抑制剂的结构亲和关系（SAR）研究。
Biochem/physiol Actions
谷氨酸的非天然异构体。
General description
D-谷氨酸是细菌肽聚糖结构的必需成分。可通过D-谷氨酸添加酶（murD）将其加入UDP-N-乙酰胞壁酰-L-丙氨酸（UDP-MurNAc-L-丙氨酸）中。然后将其掺入肽聚糖前体中。 肽聚糖构成革兰氏阳性和阴性细菌的细胞壁。通过谷氨酸消旋酶（GR）将L-谷氨酸转化为D-谷氨酸是肽聚糖合成中必不可少的步骤。
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
P Doublet et al.
Journal of bacteriology, 174(18), 5772-5779 (1992-09-01)
The murI gene of Escherichia coli, whose inactivation results in the inability to form colonies in the absence of D-glutamic acid, was identified in the 90-min region of the chromosome. The complementation of an auxotrophic E. coli B/r strain by
Matthew Volgraf et al.
Nature chemical biology, 2(1), 47-52 (2006-01-13)
The precise regulation of protein activity is fundamental to life. The allosteric control of an active site by a remote regulatory binding site is a mechanism of regulation found across protein classes, from enzymes to motors to signaling proteins. We
Katie L Whalen et al.
Molecular informatics, 30(5), 459-471 (2011-07-09)
Existing techniques which attempt to predict the affinity of protein-ligand interactions have demonstrated a direct relationship between computational cost and prediction accuracy. We present here the first application of a hybrid ensemble docking and steered molecular dynamics scheme (with a
Jia Luo et al.
Science (New York, N.Y.), 298(5592), 425-429 (2002-10-12)
The motor abnormalities of Parkinson's disease (PD) are caused by alterations in basal ganglia network activity, including disinhibition of the subthalamic nucleus (STN), and excessive activity of the major output nuclei. Using adeno-associated viral vector-mediated somatic cell gene transfer, we
H Persson et al.
Molecular and cellular biology, 10(9), 4701-4711 (1990-09-01)
The gene encoding glutamic acid decarboxylase (GAD), the key enzyme in the synthesis of the inhibitory neurotransmitter gamma-aminobutyric acid, is shown to be expressed in the testis of several different species. Nucleotide sequence analysis of a cDNA clone isolated from
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