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Merck
CN

G1046

6-姜酚

≥98% (HPLC)

别名:

3-癸酮,5-羟基-1-(4-羟基-3-甲氧基苯基)-,(5)-, 5-羟基-1-(4-羟基-3-甲氧基苯基)-3-癸酮, 6-姜辣醇

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关于此项目

经验公式(希尔记法):
C17H26O4
化学文摘社编号:
分子量:
294.39
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352205
MDL number:
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Quality Level

assay

≥98% (HPLC)

storage condition

protect from light, under inert gas

solubility

methanol: 1 mg/mL, clear, colorless

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

shipped in

dry ice

storage temp.

−20°C

SMILES string

CCCCC[C@H](O)CC(=O)CCc1ccc(O)c(OC)c1

InChI

1S/C17H26O4/c1-3-4-5-6-14(18)12-15(19)9-7-13-8-10-16(20)17(11-13)21-2/h8,10-11,14,18,20H,3-7,9,12H2,1-2H3/t14-/m0/s1

InChI key

NLDDIKRKFXEWBK-AWEZNQCLSA-N

General description

[6]-姜酚与细胞凋亡、细胞周期调节、细胞毒性活性和血管生成抑制有关。它防止血清素释放和血小板聚集。姜酚具有免疫调节、抗凋亡、抗高血糖、降血脂和止吐药的特性。

Application

[6]-姜酚已用于:
  • 研究其对瞬时受体电位(TRP)通道的影响
  • 研究其对非酒精性脂肪性肝炎实验模型的影响
  • 确定其对微粒体前列腺素E2合酶1 (mPGES-1)、糖原合酶激酶3β (GSK-3β)和A549细胞株中β-连环蛋白通路的影响
  • 分析6-姜稀酚(6-SG)对db/db小鼠糖尿病肾病(DN)的影响

Biochem/physiol Actions

存在于生姜 (Zingiber officinale) 中的具有抗氧化活性的生物活性化合物,可用作抗炎剂和抗肿瘤剂。6-姜酚通过巨噬细胞下调促炎细胞因子的释放。已证明它可通过阻断经佛波酯刺激的小鼠皮肤中 p38 MAP 激酶和 NF-κB 的活化来抑制 COX-2 的表达。


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pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves



历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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商品

Chronic inflammation is an underlying factor in the development and progression of many of the chronic diseases of aging, such as arthritis, atherosclerosis, diabetes, and cancer.


[6]-Gingerol dampens hepatic steatosis and inflammation in experimental nonalcoholic steatohepatitis
Tzeng TF, et al.
Phytomedicine, 22(4), 452-461 (2015)
Yun Xu et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 97, 633-641 (2017-11-05)
The prevalence of type 2 diabetes mellitus has been increasing worldwide and more than two thirds of the patients may develop diabetic nephropathy (DN). However, the efficiency of existing approaches on DN progression is limited. 6-Shogaol (6-SG), a major dehydrated
Biological properties of 6-gingerol: a brief review.
Wang S, et al.
Natural Product Communications, 9(7), 1027-1030 (2014)



全球贸易项目编号

货号GTIN
G1046-10MG04061833624906
G1046-5MG04061833624913