Merck
CN

G115080

Sigma-Aldrich

DMT-dG(dmf) Phosphoramidite

configured for PerkinElmer, configured for Polygen

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别名:
DMT-dG(dmf) Amidite, N-[(二甲基氨基)亚甲基]-5′-O- [双(4-甲氧基苯基)苯基甲基]-2′-脱氧鸟苷,3′-[2-氰基乙基N,N-双(1-甲基乙基)亚磷酰胺], N2-二甲基甲脒基-5′-O-(4,4′-二甲氧基三苯甲基)-2′-脱氧鸟苷-3′-O-[O-(2-氰基乙基)-N,N′-二异丙基亚]
经验公式(希尔记法):
C43H53N8O7P
分子量:
824.90
MDL编号:
PubChem化学物质编号:
NACRES:
NA.51

类型

for DNA synthesis

质量水平

产品线

Proligo Reagents

检测方案

≥99% (31P-NMR)
≥99.0% (reversed phase HPLC)

形式

powder

技术

oligo synthesis: suitable

颜色

white to off-white

λ

conforms (UV/VIS Identity)

相容性

configured for PerkinElmer
configured for Polygen

核苷分析

base: deoxyguanosine
base protecting group: DMF
2' protecting group: none
5' protecting group: DMT
deprotection: fast/standard

储存温度

−20°C

SMILES字符串

COc1ccc(cc1)C(OC[C@H]2O[C@H](C[C@@H]2OP(OCCC#N)N(C(C)C)C(C)C)n3cnc4C(=O)NC(\N=C/N(C)C)=Nc34)(c5ccccc5)c6ccc(OC)cc6

InChI

1S/C43H53N8O7P/c1-29(2)51(30(3)4)59(56-24-12-23-44)58-36-25-38(50-28-45-39-40(50)47-42(48-41(39)52)46-27-49(5)6)57-37(36)26-55-43(31-13-10-9-11-14-31,32-15-19-34(53-7)20-16-32)33-17-21-35(54-8)22-18-33/h9-11,13-22,27-30,36-38H,12,24-26H2,1-8H3,(H,47,48,52)/b46-27-/t36-,37+,38+,59?/m0/s1

InChI key

YRQAXTCBMPFGAN-UJASEYITSA-N

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一般描述

Proligo′s DNA phosphoramidites lead to high-yield and high-quality oligonucleotides due to their high coupling efficiency. The deprotection step of automated oligonucleotide synthesis is integral to synthesis time and final product quality. The high coupling efficiency of Proligo′s DNA phosphoramidites leads to high-yield and high-quality oligonucleotides.Changing the dG protecting group to the dimethylformamide (dmf) base protecting group enables the rapid synthesis of high-purity, high-yieldoligonucleotide, thus increasing the efficiency of high-throughputproduction.Key Features of dG(dmf)
  • dG(dmf) is deprotected faster than the conventional dG(ib): thedeprotection time in concentrated ammonia is reduced to 2 hours at55 °C or 1 hour at 65 °C
  • The dG(dmf)-monomer is especially suitable for G-rich sequences:incomplete deprotection is greatly reduced in comparison with theconventional dG(ib)-monomer
  • dG(dmf)-phosphoramidite is as stable in solution as the standard dA(bz)-,dC(bz)- and dT-phosphoramidites
  • dG(dmf)-phosphoramidite can directly substitute for dG(ib)-phosphoramidite
  • No change is required in the reagents commonly used for DNA synthesis(except a low concentration iodine oxidizer i.e., 0.02 M in iodine, should beemployed)DMT-dG(dmf) Phosphoramidite is configured for Expedite and PolyGen® Synthesizers.

法律信息

Expedite is a trademark of Applera Corporation or its subsidiaries in the US and/or certain other countries
PolyGen is a registered trademark of PolyGen GmbH.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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