G1251

L-谷氨酸

Name: <SC>L</SC>-谷氨酸
Brand: SIGMA

≥99% (HPLC), suitable for microbiological culture, ReagentPlus^®

别名:

(S)-2-氨基戊二酸, Glu

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线性分子式:

HO₂CCH₂CH₂CH(NH₂)CO₂H

化学文摘社编号:

56-86-0

分子量:

147.13

NACRES:

NA.26

PubChem Substance ID:

24895052

eCl@ss:

32160406

UNSPSC Code:

12352209

EC Number:

200-293-7

MDL number:

MFCD00002634

Beilstein/REAXYS Number:

1723801

主要文件

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产品名称

L-谷氨酸, ReagentPlus^®, ≥99% (HPLC)

InChI key

WHUUTDBJXJRKMK-VKHMYHEASA-N

InChI

1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1

SMILES string

N[C@@H](CCC(O)=O)C(O)=O

agency

suitable for SM 5210

product line

ReagentPlus^®

assay

≥99% (HPLC)

form

powder

technique(s)

microbiological culture: suitable

color

white to off-white

mp

205 °C (dec.) (lit.)

solubility

1 M HCl: soluble 100 mg/mL

density

1.54 g/cm³ at 20 °C

cation traces

C: 40.4-41.2%
N: 9.2-9.8%

Quality Level

200

Gene Information

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Application

L-谷氨酸已被用于增强内源性乙酰胆碱的溢出。它已被用作肉腐 莓实假单胞菌 72生长培养基中的补充剂。

Biochem/physiol Actions

一种兴奋性氨基酸神经递质，为谷氨酸盐受体所有亚型(代谢型红藻氨酸、NMDA 和 AMPA)的激动剂。

一种兴奋性氨基酸神经递质，是谷氨酸受体（代谢型、红藻氨酸盐、NMDA和AMPA）的所有亚型的激动剂。

谷氨酸或谷氨酸盐（谷氨酸的盐形式）可作为神经递质起作用，并且还可作为其他神经递质如γ-氨基丁酸的前体。谷氨酸在许多控制生长、繁殖、维持和免疫的代谢途径中也起着关键作用。它被转化为α-酮戊二酸，其是TCA（三羧酸）循环的关键组分，也是核酸和某些氨基酸生物合成的前体。在细胞中，谷氨酰胺通过酶谷氨酰胺酶转化为谷氨酸。
谷氨酰胺作为快速分裂细胞（包括淋巴细胞、肠细胞、巨噬细胞和肿瘤）的能量来源。谷氨酰胺通过细胞mTOR（雷帕霉素的哺乳动物靶标）信号转导介导蛋白质的周转。其还已报到可与细胞凋亡的抑制有关。

Legal Information

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

存储类别

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

0000490317

0000505610

0000503216

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Glutamic acid, twenty years later.

Garattini S

The Journal of Nutrition, 130, 901S-909S (2000)

Mixed carbon source utilization of meat-spoiling Pseudomonas fragi 72 in relation to oxygen limitation and carbon dioxide inhibition.

Molin G.

Applied and Environmental Microbiology, 49(6), 1442-1447 (1985)

The biology of cancer: metabolic reprogramming fuels cell growth and proliferation.

DeBerardinis RJ

Cell Metabolism, 7(1), 11-20 (2008)

Evidence for a glutamatergic modulation of the cholinergic function in the human enteric nervous system via NMDA receptors.

Cristina Giaroni et al.

European journal of pharmacology, 476(1-2), 63-69 (2003-09-13)

Several reports suggest that enteric cholinergic neurons are subject to a tonic inhibitory modulation, whereas few studies are available concerning the role of facilitatory pathways. Glutamate, the main excitatory neurotransmitter in the central nervous system (CNS), has recently been described

A Novel Bioengineered Functional Motor Unit Platform to Study Neuromuscular Interaction.

Jasdeep Saini et al.

Journal of clinical medicine, 9(10) (2020-10-15)

In many neurodegenerative and muscular disorders, and loss of innervation in sarcopenia, improper reinnervation of muscle and dysfunction of the motor unit (MU) are key pathogenic features. In vivo studies of MUs are constrained due to difficulties isolating and extracting

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Amino Acid Codon Wheel

Amino Acid Codon Wheel for fast RNA translation. Find which amino acid is translated from your RNA sequence quickly and easily.

L-谷氨酸

≥99% (HPLC), suitable for microbiological culture, ReagentPlus®

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关于此项目

主要文件

属性

产品名称

InChI key

InChI

SMILES string

agency

product line

assay

form

technique(s)

color

mp

solubility

density

cation traces

Quality Level

Gene Information

相关类别

说明

Application

Biochem/physiol Actions

Legal Information

安全信息

存储类别

wgk

flash_point_f

flash_point_c

ppe

文件

分析证书(COA)

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≥99% (HPLC), suitable for microbiological culture, ReagentPlus^®