G133
GR 89696 fumarate salt
solid
别名:
4-[(3,4-Dichlorophenyl)acetyl]-3-(1-pyrrolidinylmethyl)-1-piperazinecarboxylic acid methyl ester fumarate salt
登录 查看组织和合同定价。
选择尺寸
变更视图
关于此项目
经验公式（希尔记法）:
C19H25Cl2N3O3 · C4H4O4
化学文摘社编号:
分子量:
530.40
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Form:
solid
Quality level:
form
solid
Quality Level
color
off-white
solubility
ethanol: 4.0 mg/mL, DMSO: >50 mg/mL, H2O: 8.5 mg/mL
SMILES string
OC(=O)\C=C\C(O)=O.COC(=O)N1CCN(C(CN2CCCC2)C1)C(=O)Cc3ccc(Cl)c(Cl)c3
InChI
1S/C19H25Cl2N3O3.C4H4O4/c1-27-19(26)23-8-9-24(15(13-23)12-22-6-2-3-7-22)18(25)11-14-4-5-16(20)17(21)10-14;5-3(6)1-2-4(7)8/h4-5,10,15H,2-3,6-9,11-13H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1+
InChI key
ABTNETSDXZBJTE-WLHGVMLRSA-N
Gene Information
human ... OPRK1(4986)
Application
GR 89696 fumarate salt has been used as a κ κ2 opioid receptor (KOR) agonist to study its anti-scratching and antipruritic effects on monkeys.
Biochem/physiol Actions
GR 89696 fumarate is a selective κ2 opioid receptor agonist.
Legal Information
Sold for research purposes under agreement from GlaxoSmithKline
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
R M Caudle et al.
The Journal of pharmacology and experimental therapeutics, 283(3), 1342-1349 (1998-02-12)
Receptor binding studies and electrophysiological studies demonstrated the existence of at least two kappa opioid receptors, which have been designated kappa-1 and kappa-2. Several agonists and antagonists are selective for the kappa-1 receptor whereas no known ligands are selective for
A Butler et al.
British journal of pharmacology, 109(1), 126-130 (1993-05-01)
1. Effects of the alpha 2-adrenoceptor agonists, UK14304 and clonidine, the 5-HT1 receptor agonist, sumatriptan and the kappa-opioid receptor agonist, GR103545, on sensory neurotransmission in histamine-contracted guinea-pig isolated pulmonary artery (GPPA) have been studied. 2. Electrical field stimulation (EFS) induced
B Fry et al.
Neuropeptides, 35(3-4), 154-161 (2002-03-09)
Isometric muscle contractions cause an increase in mean arterial pressure and heart rate. Previously, we showed that substance P (SP) is released from sites in the feline medial nucleus tractus solitarius (mNTS) in response to isometric muscle contractions, and that
Mei-Chuan Ko et al.
The Journal of pharmacology and experimental therapeutics, 328(1), 193-200 (2008-10-10)
Itch/pruritus is the most common side effect associated with spinal administration of morphine given to humans for analgesia. The aim of this study was to investigate the effectiveness of kappa-opioid receptor (KOR) agonists with diverse chemical structures as antipruritics and
Peter S Talbot et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 46(3), 484-494 (2005-03-08)
Brain kappa-opioid receptors (ORs) may be involved in several pathologic conditions, such as addiction, psychosis, and seizures. (+/-)-4-Methoxycarbonyl-2-[(1-pyrrolidinylmethyl]-1-[(3,4-dichlorophenyl)acetyl]-piperidine (GR89696) is a potent and selective kappa-OR agonist. The (-)-isomer, GR103545, is the active enantiomer of GR89696. The aim of this study
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| G133-25MG | 04061832556628 |
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持