G133
GR 89696 fumarate salt
solid
别名:
4-[(3,4-Dichlorophenyl)acetyl]-3-(1-pyrrolidinylmethyl)-1-piperazinecarboxylic acid methyl ester fumarate salt
登录查看公司和协议定价
选择尺寸
关于此项目
经验公式（希尔记法）:
C19H25Cl2N3O3 · C4H4O4
化学文摘社编号:
分子量:
530.40
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
表单
solid
颜色
off-white
溶解性
ethanol: 4.0 mg/mL
DMSO: >50 mg/mL
H2O: 8.5 mg/mL
SMILES字符串
OC(=O)\C=C\C(O)=O.COC(=O)N1CCN(C(CN2CCCC2)C1)C(=O)Cc3ccc(Cl)c(Cl)c3
InChI
1S/C19H25Cl2N3O3.C4H4O4/c1-27-19(26)23-8-9-24(15(13-23)12-22-6-2-3-7-22)18(25)11-14-4-5-16(20)17(21)10-14;5-3(6)1-2-4(7)8/h4-5,10,15H,2-3,6-9,11-13H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1+
InChI key
ABTNETSDXZBJTE-WLHGVMLRSA-N
基因信息
human ... OPRK1(4986)
应用
GR 89696 fumarate salt has been used as a κ κ2 opioid receptor (KOR) agonist to study its anti-scratching and antipruritic effects on monkeys.
生化/生理作用
GR 89696 fumarate is a selective κ2 opioid receptor agonist.
法律信息
Sold for research purposes under agreement from GlaxoSmithKline
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
A Iu Lishmanov et al.
Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 92(12), 1419-1428 (2007-05-26)
It was found that pretreatment of rats with selective agonist of kappa1-opioid receptors (OR) (-)--U--50.488 decreased the incidence of ischemic (10 min) and reperfusion (10 min) ventricular arrhythmias. The selective kappa2-OR agonist GR-89696 had no effect on the incidence of
Yu B Lishmanov et al.
Bulletin of experimental biology and medicine, 145(6), 696-699 (2008-12-27)
Chronic treatment with opioid receptor ligands: nonselective peptide opioid receptor agonist dalargin (intraperitoneally in a dose of 1 mg/kg), selective nonpeptide kappa-receptor agonist GR 89696 (subcutaneously in a dose of 0.03 mg/kg), nonselectrive nonpeptide antagonist quadazocine (subcutaneously in a dose
Woong Mo Kim et al.
Anesthesia and analgesia, 113(4), 934-940 (2011-07-27)
Although bone cancer-related pain is one of the most disruptive symptoms in patients with advanced cancer, patients are often refractory to pharmacological treatments; thus, more effective treatments for bone cancer pain are needed. We evaluated the analgesic efficacy of and
Baojun Gu et al.
The Journal of urology, 171(1), 472-477 (2003-12-11)
The nonselective kappa opioid receptor agonist ethylketocyclazocine suppresses external urethral sphincter (EUS) reflexes in cats. We examined the role of spinal kappa-opioid receptor subtypes in the control of EUS function in rats using selective kappa-1 (U-50,488) or kappa-2 (GR-89,696) opiate
Peter S Talbot et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 46(3), 484-494 (2005-03-08)
Brain kappa-opioid receptors (ORs) may be involved in several pathologic conditions, such as addiction, psychosis, and seizures. (+/-)-4-Methoxycarbonyl-2-[(1-pyrrolidinylmethyl]-1-[(3,4-dichlorophenyl)acetyl]-piperidine (GR89696) is a potent and selective kappa-OR agonist. The (-)-isomer, GR103545, is the active enantiomer of GR89696. The aim of this study
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持