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Merck
CN

G154

加巴喷丁

≥98% (HPLC), solid, anticonvulsant

别名:

1-（氨甲基）-环己烷乙酸, 加巴喷丁

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关于此项目

经验公式（希尔记法）:
C9H17NO2
化学文摘社编号:
60142-96-3
分子量:
171.24
NACRES:
NA.77
PubChem Substance ID:
24278159
UNSPSC Code:
12352200
EC Number:
262-076-3
MDL number:
MFCD00865286
Beilstein/REAXYS Number:
2359739

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产品名称

加巴喷丁, solid

InChI key

UGJMXCAKCUNAIE-UHFFFAOYSA-N

InChI

1S/C9H17NO2/c10-7-9(6-8(11)12)4-2-1-3-5-9/h1-7,10H2,(H,11,12)

SMILES string

NCC1(CC(O)=O)CCCCC1

form

solid

color

off-white

solubility

H2O: 10 mg/mL

Quality Level

200

Gene Information

human ... ADORA1(134), CACNA1A(773), CACNA1B(774), CACNA1C(775), CACNA1D(776), CACNA1E(777), CACNA1F(778), CACNA1G(8913), CACNA1H(8912), CACNA1I(8911), CACNA1S(779), CACNA2D1(781), CACNA2D2(9254), CACNA2D3(55799), CACNA2D4(93589), CACNB1(782), CACNB2(783), CACNB3(784), CACNB4(785), CACNG1(786), CACNG2(10369), CACNG3(10368), CACNG4(27092), CACNG5(27091), CACNG6(59285), CACNG7(59284), CACNG8(59283)
rat ... Cacna1a(25398)

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相关类别

Biochem/physiol Actions

作用机制不明的抗惊厥药；可通过血脑屏障；增加脑内 GABA 浓度，减少兴奋性氨基酸神经传递，可能是通过其对电压门控钙通道的作用；表现出抗伤害、抗焦虑、神经保护和抗癫痫作用。
加巴喷丁作为 L 型钙通道 α2δ 亚单位的配体。

Application

加巴喷丁已被用于：
  • 作为 α2δ-配体，以检查异硫氰酸烯丙酯 (AITC) 敏化热厌恶试验是否可作为鉴别假定镇痛药的筛选方法
  • 溶于摄取缓冲液，使用液相色谱-质谱法通过有机阳离子转运蛋白 2 (OCTN2) 测定 ASP（反式-4-[4-（二甲氨基）苯乙烯基]-1-甲基吡啶碘）底物
  • 用作腹腔内注射的镇痛佐剂

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000512520
0000512520
0000512514
0000512514
0000450312

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Journal of medicinal chemistry, 48(7), 2294-2307 (2005-04-02)
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During virus entry, members of the Polyomaviridae transit the endolysosomal network en route to the endoplasmic reticulum (ER), from which degraded capsids escape into the cytoplasm and enter the nucleus. Emerging evidence suggests that viruses require both endosomal acidification and
Michael F Jarvis et al.
Proceedings of the National Academy of Sciences of the United States of America, 104(20), 8520-8525 (2007-05-08)
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Silke Grigat et al.
Drug metabolism and disposition: the biological fate of chemicals, 37(2), 330-337 (2008-11-05)
In addition to its function as carnitine transporter, novel organic cation transporter type 2 (OCTN2; human gene symbol SLC22A5) is widely recognized as a transporter of drugs. This notion is based on several reports of direct measurement of drug accumulation.
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