G1639
D-(+)-半乳糖胺 盐酸盐
BioReagent, suitable for cell culture
别名:
2-氨基-2-脱氧-D-半乳糖 盐酸盐, D-软骨糖胺 盐酸盐
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关于此项目
经验公式（希尔记法）:
C6H13NO5 · HCl
化学文摘社编号:
分子量:
215.63
PubChem Substance ID:
UNSPSC Code:
12352209
MDL number:
NACRES:
NA.75
EC Number:
217-198-1
Beilstein/REAXYS Number:
3697825
InChI key
CBOJBBMQJBVCMW-NQZVPSPJSA-N
InChI
1S/C6H13NO5.ClH/c7-3(1-8)5(11)6(12)4(10)2-9;/h1,3-6,9-12H,2,7H2;1H/t3-,4+,5+,6-;/m0./s1
SMILES string
Cl.N[C@@H](C=O)[C@@H](O)[C@@H](O)[C@H](O)CO
biological source
fish cartilage (shark)
product line
BioReagent
assay
≥99%
technique(s)
cell culture | mammalian: suitable
impurities
Glucosamine, essentially free
solubility
water: 50 mg/mL, clear to very slightly hazy, colorless to very faintly yellow
shipped in
ambient
storage temp.
room temp
Quality Level
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Application
使用D-(+)-半乳糖胺盐：
- 诱导小鼠肝损伤
- 炎症性肝损伤
- 急性肝衰竭(ALF)
Biochem/physiol Actions
半乳糖胺(D-GalN)由半乳糖合成，是一种潜在的肝毒剂。D-GalN与脂多糖结合可导致致命性肝损伤和肝衰竭的恶化。它使细胞对细胞因子，特别是肿瘤坏死因子(TNF)的毒性作用变得敏感。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Yao Wang et al.
Journal of inflammation research, 14, 1473-1485 (2021-04-23)
The glycolysis pathway of M1 macrophages is a key factor affecting the inflammatory response. The aim of this article is to investigate the role of histone deacetylase 6 (HDAC6) in the M1 macrophage glycolysis pathway during acute liver failure (ALF).
GABA, gamma-Aminobutyric Acid, Protects Against Severe Liver Injury
Hata T, et al.
The Journal of Surgical Research, 236, 172-183 (2019)
The protective effect of the natural compound hesperetin against fulminant hepatitis in vivo and in vitro
Bai X, et al.
British Journal of Pharmacology, 174(1), 41-56 (2017)
Catalpol protects mice against Lipopolysaccharide/D-galactosamine-induced acute liver injury through inhibiting inflammatory and oxidative response
Zhang H, et al.
Testing, 9(3), 3887-3887 (2018)
Voluntary distance running prevents TNF-mediated liver injury in mice through alterations of the intrahepatic immune milieu
Huber Y, et al.
Cell Death & Disease, 8(6), e2893-e2893 (2017)
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