G1639
D-(+)-半乳糖胺 盐酸盐
BioReagent, suitable for cell culture
别名:
2-氨基-2-脱氧-D-半乳糖 盐酸盐, D-软骨糖胺 盐酸盐
生物来源
fish cartilage (shark)
质量水平
产品线
BioReagent
方案
≥99%
技术
cell culture | mammalian: suitable
杂质
Glucosamine, essentially free
溶解性
water: 50 mg/mL, clear to very slightly hazy, colorless to very faintly yellow
运输
ambient
储存温度
room temp
SMILES字符串
Cl.N[C@@H](C=O)[C@@H](O)[C@@H](O)[C@H](O)CO
InChI
1S/C6H13NO5.ClH/c7-3(1-8)5(11)6(12)4(10)2-9;/h1,3-6,9-12H,2,7H2;1H/t3-,4+,5+,6-;/m0./s1
InChI key
CBOJBBMQJBVCMW-NQZVPSPJSA-N
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应用
使用D-(+)-半乳糖胺盐：
- 诱导小鼠肝损伤
- 炎症性肝损伤
- 急性肝衰竭(ALF)
生化/生理作用
半乳糖胺(D-GalN)由半乳糖合成，是一种潜在的肝毒剂。D-GalN与脂多糖结合可导致致命性肝损伤和肝衰竭的恶化。它使细胞对细胞因子，特别是肿瘤坏死因子(TNF)的毒性作用变得敏感。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
D-galactosamine lethality model: scope and limitations
Silverstein R
Journal of endotoxin research, 10(3), 147-162 (2004)
The protective effect of the natural compound hesperetin against fulminant hepatitis in vivo and in vitro
Bai X, et al.
British Journal of Pharmacology, 174(1), 41-56 (2017)
Catalpol protects mice against Lipopolysaccharide/D-galactosamine-induced acute liver injury through inhibiting inflammatory and oxidative response
Zhang H, et al.
Testing, 9(3), 3887-3887 (2018)
Voluntary distance running prevents TNF-mediated liver injury in mice through alterations of the intrahepatic immune milieu
Huber Y, et al.
Cell Death & Disease, 8(6), e2893-e2893 (2017)
GABA, gamma-Aminobutyric Acid, Protects Against Severe Liver Injury
Hata T, et al.
The Journal of Surgical Research, 236, 172-183 (2019)
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