Quality Level
assay
≥99%
mp
82-86 °C (lit.)
shipped in
dry ice
storage temp.
−20°C
SMILES string
O=C1COC(=O)CO1
InChI
1S/C4H4O4/c5-3-1-7-4(6)2-8-3/h1-2H2
InChI key
RKDVKSZUMVYZHH-UHFFFAOYSA-N
General description
乙交酯是α羟基酸的环状二聚体，可用于制备脂肪族聚酯。它通过甘醇酸的二聚化而合成。它可制备低毒的人造生物可降解聚合物，适于医疗应用。它主要用于通过开环聚合反应形成高度结晶的聚乙交酯。
Application
乙交酯可作为单体与丙交酯单体共聚制备聚乳酸-乙交酯共聚物(PGLA)。PGLA进一步用于以下应用：
- 多孔PGLA微球支架应用于骨修复。
- 封装PGLA纳米颗粒可用于药物输送和组织工程应用。因具有众多特性，包括生物可降解性、生物相容性、延长药物释放时间和保护药物不被降解，由PLGA制成的聚合物微/纳米颗粒引起了广泛关注。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Biomedical applications of PLGA particles
Agrawal A, et al.
Materials for Biomedical Engineering, 87-129 (2019)
Towards electroactive gel artificial muscle structures
Electroactive Polymer Actuators and Devices (EAPAD) XX, 10594, 1059408-1059408 (2018)
Anne Marit de Groot et al.
Journal of controlled release : official journal of the Controlled Release Society, 266, 27-35 (2017-09-18)
The skin is an attractive organ for immunization due to the presence of a large number of epidermal and dermal antigen-presenting cells. Hollow microneedles allow for precise and non-invasive intradermal delivery of vaccines. In this study, ovalbumin (OVA)-loaded poly(lactic-co-glycolic acid)
Neda Khameh Khorshid et al.
Macromolecular bioscience, 16(12), 1838-1852 (2016-10-16)
The thermoresponsive amphiphilic block copolymer poly(d,l-lactic acid-co-glycolic acid)-block-poly(ethylene glycol)-block-poly(d,l-lactic acid-co-glycolic acid) (PLGA-PEGn -PLGA), which exhibits a reversible temperature-induced sol-gel transition at higher polymer concentrations in aqueous solution has attached a great deal of interest because of its potential in biomedical
Types of biodegradable polymers
Introduction of Bioplastic Engineering, 81-151 (2016)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| G1796-25G | 04061833628409 |
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