Merck
CN

G1796

Sigma-Aldrich

乙交酯

≥99%

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别名:
1,4-二氧杂环-2,5-己二酮
经验公式(希尔记法):
C4H4O4
CAS号:
分子量:
116.07
EC 号:
MDL编号:
PubChem化学物质编号:
NACRES:
NA.23

检测方案

≥99%

mp

82-86 °C (lit.)

运输

dry ice

储存温度

−20°C

SMILES string

O=C1COC(=O)CO1

InChI

1S/C4H4O4/c5-3-1-7-4(6)2-8-3/h1-2H2

InChI key

RKDVKSZUMVYZHH-UHFFFAOYSA-N

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一般描述

乙交酯是α羟基酸的环状二聚体,可用于制备脂肪族聚酯。它通过甘醇酸的二聚化而合成。它可制备低毒的人造生物可降解聚合物,适于医疗应用。它主要用于通过开环聚合反应形成高度结晶的聚乙交酯。

应用

乙交酯可作为单体与丙交酯单体共聚制备聚乳酸-乙交酯共聚物(PGLA)。PGLA进一步用于以下应用:
  • 多孔PGLA微球支架应用于骨修复。
  • 封装PGLA纳米颗粒可用于药物输送和组织工程应用。因具有众多特性,包括生物可降解性、生物相容性、延长药物释放时间和保护药物不被降解,由PLGA制成的聚合物微/纳米颗粒引起了广泛关注。
也可用于合成聚乙二醇-己内酯(PGCL)共聚物,后者可作为生物可吸收缝合材料。

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Acute Tox. 4 Oral - Eye Irrit. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves


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  1. How does the storage temperature relate to shipping conditions?

    The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment. See Shipping and Storage for more information.

  2. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  3. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  4. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  5. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  6. What is glycoline (Product No. G1796) soluble in?

    Prior to gas chromatography we solubilize this product in methylene chloride at a concentration of 20 mg/mL.

  7. What is the residual solvent content in Product No. G1796. Glycolide?

    Residual solvent has been reported for this product as less than 0.1%.

  8. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

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