G1895
甘氨酸-脯氨酸-精氨酸-脯氨酸
≥95% (HPLC), fibrin polymerization inhibitor
别名:
GPRP, Glycyl-Prolyl-Arginyl-Proline amide
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关于此项目
经验公式（希尔记法）:
C18H31N7O5
化学文摘社编号:
分子量:
425.48
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.32
MDL number:
产品名称
甘氨酸-脯氨酸-精氨酸-脯氨酸, ≥95% (HPLC)
SMILES string
NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N2CCC[C@H]2C(O)=O
InChI
1S/C18H31N7O5/c19-10-14(26)24-8-2-5-12(24)15(27)23-11(4-1-7-22-18(20)21)16(28)25-9-3-6-13(25)17(29)30/h11-13H,1-10,19H2,(H,23,27)(H,29,30)(H4,20,21,22)/t11-,12-,13-/m0/s1
InChI key
WXPZDDCNKXMOMC-AVGNSLFASA-N
assay
≥95% (HPLC)
storage temp.
−20°C
Quality Level
Gene Information
human ... FN1(2335)
mouse ... FN1(14268)
rat ... FN1(25661)
General description
Gly-Pro-Arg-Pro是一种模拟纤维蛋白α链的N-末端Gly-Pro-Arg区域的肽。
Application
Gly-Pro-Arg-Pro（GPRP）已被用于形成由GPRP和来自血纤维蛋白原γ链的30kDa C末端片段（rFbgγC30）组成的晶体，其中，rFbgγC30是在 酵母中克隆和表达的。
Biochem/physiol Actions
Gly-Pro-Arg-Pro（GPRP）能够增加游离凝血酶。因此，它可用于制备凝血酶脱粒的（thrombin-degranulated）血小板，其有助于研究血小板反应。
抑制纤维蛋白聚合。
Gly-Pro-Arg-Pro肽能够抑制纤维蛋白聚合的早期阶段。即使是存在EGTA（乙二醇-双（β-氨基乙基醚）-N,N,N′,N′-四乙酸）的情况下，该肽的酰胺衍生物也能抑制纤溶酶对纤维蛋白原和片段D的降解。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
此项目有
Ramesh Ramapanicker et al.
Bioconjugate chemistry, 24(1), 17-25 (2012-11-16)
The synthetic tetrapeptide GPRP based on the amino-terminal GPR sequence of the fibrin α-chain binds the D-dimer protein with a dissociation constant K(D) of 25 μM. The D-dimer protein, a well-known biomarker for thrombosis, contains two cross-linked D fragments from
Katharina Neubauer et al.
Cytoskeleton (Hoboken, N.J.), 76(1), 131-136 (2018-07-19)
Hereditary neuralgic amyotrophy (HNA) is an autosomal dominant disorder associated with episodic, recurrent, and painful neuropathies affecting the nerves of the brachial plexus. In this study, we report on a family of Lebanese descent with HNA onset in early childhood.
U Haddeland et al.
Thrombosis and haemostasis, 75(2), 326-331 (1996-02-01)
The present paper shows that conformationally changed fibrinogen can expose the sites A alpha-(148-160) and gamma-(312-324) involved in stimulation of the tissue-type plasminogen activator (t-PA)-catalysed plasminogen activation. The exposure of the stimulating sites was determined by ELISA using mABs directed
The use of the synthetic peptide, Gly-Pro-Arg-Pro, in the preparation of thrombin-degranulated rabbit platelets
Harfenist EJ, et al.
Blood, 59(5), 952-955 (1982)
N Li et al.
European journal of haematology, 65(1), 57-65 (2000-07-29)
A flow cytometric assay for measurements of leukocyte CD11b expression in whole blood has been developed and evaluated. The method is based on triggering of the flow cytometer by a fluorescent pan leukocyte marker, RPE-CD45. This enabled flow cytometric analysis
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