G1895
甘氨酸-脯氨酸-精氨酸-脯氨酸
≥95% (HPLC), fibrin polymerization inhibitor
别名:
GPRP, Glycyl-Prolyl-Arginyl-Proline amide
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关于此项目
经验公式（希尔记法）:
C18H31N7O5
CAS Number:
分子量:
425.48
MDL编号:
UNSPSC代码:
12352209
PubChem化学物质编号:
NACRES:
NA.32
Product Name
甘氨酸-脯氨酸-精氨酸-脯氨酸, ≥95% (HPLC)
质量水平
方案
≥95% (HPLC)
储存温度
−20°C
SMILES字符串
NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N2CCC[C@H]2C(O)=O
InChI
1S/C18H31N7O5/c19-10-14(26)24-8-2-5-12(24)15(27)23-11(4-1-7-22-18(20)21)16(28)25-9-3-6-13(25)17(29)30/h11-13H,1-10,19H2,(H,23,27)(H,29,30)(H4,20,21,22)/t11-,12-,13-/m0/s1
InChI key
WXPZDDCNKXMOMC-AVGNSLFASA-N
基因信息
human ... FN1(2335)
mouse ... FN1(14268)
rat ... FN1(25661)
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相关类别
Amino Acid Sequence
Gly-Pro-Arg-Pro
一般描述
Gly-Pro-Arg-Pro是一种模拟纤维蛋白α链的N-末端Gly-Pro-Arg区域的肽。
应用
Gly-Pro-Arg-Pro（GPRP）已被用于形成由GPRP和来自血纤维蛋白原γ链的30kDa C末端片段（rFbgγC30）组成的晶体，其中，rFbgγC30是在 酵母中克隆和表达的。
生化/生理作用
Gly-Pro-Arg-Pro肽能够抑制纤维蛋白聚合的早期阶段。即使是存在EGTA（乙二醇-双（β-氨基乙基醚）-N,N,N′,N′-四乙酸）的情况下，该肽的酰胺衍生物也能抑制纤溶酶对纤维蛋白原和片段D的降解。
Gly-Pro-Arg-Pro（GPRP）能够增加游离凝血酶。因此，它可用于制备凝血酶脱粒的（thrombin-degranulated）血小板，其有助于研究血小板反应。
抑制纤维蛋白聚合。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
B Shenkman et al.
The Journal of laboratory and clinical medicine, 135(1), 43-51 (2000-01-19)
Recent studies emphasize the role of blood constituents in Staphylococcus aureus (S. aureus) adherence to subendothelial extracellular matrix. In the present study, the adherence of two strains of S. aureus (ATCC 29213 and RN 6390) grown to a postexponential phase
The use of the synthetic peptide, Gly-Pro-Arg-Pro, in the preparation of thrombin-degranulated rabbit platelets
Harfenist EJ, et al.
Blood, 59(5), 952-955 (1982)
N Li et al.
European journal of haematology, 65(1), 57-65 (2000-07-29)
A flow cytometric assay for measurements of leukocyte CD11b expression in whole blood has been developed and evaluated. The method is based on triggering of the flow cytometer by a fluorescent pan leukocyte marker, RPE-CD45. This enabled flow cytometric analysis
Elena Monzón Manzano et al.
British journal of haematology, 189(5), 943-953 (2020-01-17)
Multifactorial mechanisms leading to diminished platelet counts in immune thrombocytopaenia (ITP) might condition the ability of patients with ITP to respond to treatments. Examining their platelet and immune features, we aimed to detect singular characteristics of patients with ITP who
V Blanco-Abad et al.
Developmental and comparative immunology, 87, 147-156 (2018-06-24)
Many studies have shown that coagulation systems play an important role in the defence against pathogens in invertebrates and vertebrates. In vertebrates, particularly in mammals, it has been established that the coagulation system participates in the entrapment of pathogens and
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