G2171

GW843682X

Name: GW843682X
Brand: SIGMA

≥98% (HPLC), solid

别名:

5-(5,6-dimethoxy-1H-benzimidazol-1-yl)-3-{[2-(trifluoromethyl)-benzyl]oxy}thiophene-2-carboxamide, GW843682

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About This Item

经验公式（希尔记法）:

C₂₂H₁₈F₃N₃O₄S

CAS Number:

660868-91-7

分子量:

477.46

MDL编号:

MFCD09971143

UNSPSC代码:

12352200

PubChem化学物质编号:

329799898

NACRES:

NA.77

主要文件

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质量水平

100

方案

≥98% (HPLC)

表单

solid

颜色

off-white

溶解性

DMSO: >10 mg/mL

创始人

GlaxoSmithKline

储存温度

2-8°C

SMILES字符串

COc1cc2ncn(-c3cc(OCc4ccccc4C(F)(F)F)c(s3)C(N)=O)c2cc1OC

InChI

1S/C22H18F3N3O4S/c1-30-16-7-14-15(8-17(16)31-2)28(11-27-14)19-9-18(20(33-19)21(26)29)32-10-12-5-3-4-6-13(12)22(23,24)25/h3-9,11H,10H2,1-2H3,(H2,26,29)

InChI key

JSKUWFIZUALZLX-UHFFFAOYSA-N

应用

GW843682X has been used as a polo-like kinase-1 (PLK1) inhibitor:

to study the influence of PLK1 inhibition on Wee1 (G2 check point kinase), cyclin-dependent protein kinase 1 (Cdc2)–Yp15, expression in melanoma cells
to determine if PLK1 inhibition decreased the survival of hamartin and tuberin deficient cells
to investigate if inhibitors of PLK1 and aurora kinases have a synergistic antimitotic impact in HeLa cells

生化/生理作用

GW843682X is a polo-like kinase-1 (PLK1) and polo-like kinase-3 (PLK3) inhibitor with nanomolar activity. It shows potent inhibition of proliferation of a wide variety of tumor cell lines.

GW843682X is an anti-cancer compound. It can improve the ability of vincristine to promote growth arrest and apoptosis in leukemia cells. GW843682X is capable of disturbing the formation of spindles and terminate mitoses in lung adenocarcinoma cells.

特点和优势

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.