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Merck
CN

G3545

GW583340 dihydrochloride

≥97% (HPLC), solid

别名:

4-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenylamino]-6-[2-[[2-(methylsulfonyl)ethyl]aminomethyl]-4-thiazolyl]quinazoline dihydrochloride

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关于此项目

经验公式（希尔记法）:
C28H25ClFN5O3S2 · 2HCl
化学文摘社编号:
1173023-85-2
分子量:
671.03
NACRES:
NA.77
PubChem Substance ID:
24895131
UNSPSC Code:
51111800
MDL number:
MFCD07370137
Assay:
≥97% (HPLC)
Form:
solid

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InChI key

WIMITXDBYLKRKB-UHFFFAOYSA-N

SMILES string

Cl[H].Cl[H].CS(=O)(=O)CCNCc1nc(cs1)-c2ccc3ncnc(Nc4ccc(OCc5cccc(F)c5)c(Cl)c4)c3c2

InChI

1S/C28H25ClFN5O3S2.2ClH/c1-40(36,37)10-9-31-14-27-35-25(16-39-27)19-5-7-24-22(12-19)28(33-17-32-24)34-21-6-8-26(23(29)13-21)38-15-18-3-2-4-20(30)11-18;;/h2-8,11-13,16-17,31H,9-10,14-15H2,1H3,(H,32,33,34);2*1H

assay

≥97% (HPLC)

form

solid

mp

259.8-262.4 °C (lit.)

solubility

DMSO: 9 mg/mL

originator

GlaxoSmithKline

storage temp.

2-8°C

相关类别

Biochem/physiol Actions

Potent dual ErbB-2/EGFR tyrosine kinase inhibitor. IC50= 0.01 and 0.014 μM for EGFR and ErbB-2. Orally active.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

Sold for research purposes under agreement from Glaxo­Smith­Kline

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
015K4703

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