G3637
Cohn组分IV球蛋白 人
一般描述
Cohn 馏分 IV 由 α 和 β-球蛋白组成。它是 γ-球蛋白合成过程中产生的血浆副产物。
应用
人球蛋白 Cohn 部分 IV-4 已用在差示扫描量热法（DSC） 中测试低剂量电离辐射的效果。它还被用于制备用于生物物理研究的血浆蛋白溶液。
球蛋白可以将 5-甲氧基补骨脂素与血液组分结合。可用作粒细胞免疫荧光试验（GIFT）的阳性对照。它还可用于研究人血清蛋白混合物的热变性。
生化/生理作用
Cohn 组分 IV（富含 α-珠蛋白）介导脑神经递质受体的抑制。
其他说明
主要是 α-和 β-球蛋白
免责声明
仅供研究使用。本品在法国的科研应用受到监管，包括用于进口和出口活动（法国《公共卫生法典》Public Health Code Article L 1211-1 paragraph 2）。如《公共卫生法典》所述，购买者（即最终用户）需要从法国研究部(France Ministry of Research)获得进口授权。订购此产品即代表您已确认获得合法的进口授权。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
高风险级别生物产品--人源产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Yvonne Rosenberg et al.
Neuropharmacology, 174, 108150-108150 (2020-05-23)
More frequent and widespread nerve agent attacks highlight the need for efficacious pre- and post-exposure organophosphate (OP) counter-measures to protect military and civilian populations. Because of critical targeting of acetylcholinesterase (AChE) in the CNS by OPs, a pre-treatment candidate for
A C Andorn et al.
Proceedings of the National Academy of Sciences of the United States of America, 83(12), 4572-4575 (1986-06-01)
Human serum proteins are found in significant density in the neuropil in brains of demented individuals. The functional significance of these abnormally distributed proteins has been unknown. We now report that alpha-globulin-enriched fractions of human serum decrease the specific binding
P Muret et al.
Skin pharmacology : the official journal of the Skin Pharmacology Society, 6(1), 45-51 (1993-01-01)
The binding of 5-methoxypsoralen (5-MOP) to human serum and blood fractions was studied by equilibrium dialysis associated to high-performance liquid chromatography. 5-MOP serum binding was 95% and kept constant in the range of therapeutic concentrations. Albumin was the main binding
Effects of low-dose ionizing radiation on alpha, beta-globulins solutions studied by DSC
Michnik A, et al.
Journal of Thermal Analysis and Calorimetry, 111(3), 1845-1852 (2013)
N E Riera et al.
International journal of laboratory hematology, 32(1 Pt 1), e96-105 (2009-07-15)
Immune humoral neutropenia (Np) could be the consequence of anti-polymorphonuclear neutrophil (PMN) antibodies, circulating immune complexes (CIC) and/or antibodies against myeloid precursors. Granulocyte immunofluorescence test (GIFT) and a leukoagglutination technique (LAGT) assays are recommended for its diagnosis. Fifty adult patients
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