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About This Item
经验公式（希尔记法）:
C18H12N4O3
CAS Number:
分子量:
332.31
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
red
溶解性
DMSO: >10 mg/mL
储存温度
room temp
SMILES字符串
[O-][N+](=O)c1ccc(Nc2ccccc2-c3ccccc3)c4nonc14
InChI
1S/C18H12N4O3/c23-22(24)16-11-10-15(17-18(16)21-25-20-17)19-14-9-5-4-8-13(14)12-6-2-1-3-7-12/h1-11,19H
InChI key
KMJPYSQOCBYMCF-UHFFFAOYSA-N
生化/生理作用
10074-G5 is a c-Myc/Max interaction inhibitor.
10074-G5 is a c-Myc/Max interaction inhibitor. The c-Myc oncoprotein and its partner Max are intrinsically disordered (ID) monomers that undergo coupled folding and binding upon heterodimerization. 10074-G5, similarly to 10058-F4 (#F3680), specifically inhibits this interaction by binding to c-Myc, thus preventing C-Myc specific DNA binding and target genes regulation. 10074-G5 (2.8 microM) is slightly more potent that 10058-F4 (5.2 microM). It was discovered that 10074-G5 binds to a different specific binding site (region) of C-Myc than 10054-F4. Thus, the compound may become desirable for probing different interactions.
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
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