form
lyophilized powder
specific activity
≥30 units/mg protein
composition
Protein, 13-25% modified Warburg-Christian
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
Gene Information
human ... GPX1(2876)
General description
GPX1(谷胱甘肽过氧化物酶 1)属于 GPXs 的四元家族,包括 GPX2、GPX3 和 GPX4。它是一种含硒半胱氨酸的蛋白质。GPX1 是 GPX 酶的主要亚型,广泛存在于细胞内。
注意:在报道的最适 pH 值 8.8 下,我们发现活性约为pH 7.0 时的 10 倍。但是,为了与文献保持一致,避免与 GSH 的非酶催化氧化反应混淆,我们的单位仍在 pH 7.0 下定义。
Application
来自人红细胞的谷胱甘肽过氧化物酶 (GPX) 已被用于测定从皮肤鳞状细胞癌 (CSCC) 或日光性角化病 (SK) 获得的上皮片中过氧化物灭活 GPX 的能力。
Biochem/physiol Actions
GPX1(谷胱甘肽过氧化物酶 1)利用还原型谷胱甘肽 (GSH) 作为电子供体,催化多种有机和无机过氧化物的转化。这种酶还负责清除有机和无机过氧化物。
Physical form
含 25% 蔗糖和 3% 二硫苏糖醇以及磷酸钠缓冲盐的冻干粉
Other Notes
在pH7.0,25℃下,一个单元将催化H2O2氧化1.0 μmol的还原型谷胱甘肽至氧化型谷胱甘肽。
signalword
Danger
hcodes
Hazard Classifications
Resp. Sens. 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
O L Gostukhina et al.
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Hai-Dong Yao et al.
The Journal of nutrition, 143(5), 613-619 (2013-03-22)
Dietary selenium (Se) deficiency causes muscular dystrophy in various species, but the molecular mechanism remains unclear. Our objectives were to investigate: 1) if dietary Se deficiency induced different amounts of oxidative stress, lipid peroxidation, and cell apoptosis in 3 skeletal
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Environmental toxicology and chemistry, 32(6), 1420-1425 (2013-02-19)
The effect of sodium chloride (NaCl) on cadmium (Cd) uptake, translocation, and oxidative stress was investigated using 2 tobacco cultivars differing in Cd tolerance. The growth inhibition of the tobacco plants exposed to Cd toxicity was in part alleviated by
Walter A Baseler et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 304(7), R553-R565 (2013-02-15)
Mitochondrial dysfunction is a contributor to diabetic cardiomyopathy. Previously, we observed proteomic decrements within the inner mitochondrial membrane (IMM) and matrix of diabetic cardiac interfibrillar mitochondria (IFM) correlating with dysfunctional mitochondrial protein import. The goal of this study was to
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Circulation, 127(12), 1308-1316 (2013-02-22)
The incidence of thrombotic events increases during aging, but the mechanisms are not well understood. To investigate the prothrombotic role of oxidative stress during aging, we tested the hypothesis that aged mice overexpressing the antioxidant enzyme glutathione peroxidase-1 (Gpx1) are
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| 货号 | GTIN |
|---|---|
| G4013-10UN | 04061833492802 |
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