recombinant
expressed in baculovirus infected Sf9 cells
Quality Segment
product line
PRECISIO® Kinase
assay
≥70% (SDS-PAGE)
form
buffered aqueous glycerol solution
specific activity
143-193 nmol/min·mg
mol wt
~48 kDa
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... GSK3B(2932)
General description
Biochem/physiol Actions
GSK3是一种丝氨酸-苏氨酸蛋白激酶,最初被确定为磷酸化和抑制糖原合成酶的激酶。GSK3普遍存在于人体组织中,并参与多种生理过程的调节,包括胰岛素对糖原和蛋白质合成的控制以及转录因子AP-1和CREB的调节。人类GSK3瞬时转染到稳定转染了各人类tau异构体的中国仓鼠卵巢细胞中,导致tau蛋白在所有被磷酸化依赖性抗tau抗体检测的位点上过度磷酸化。
Physical form
50 mM 磷酸氢二钠 pH 7.0、300 mm NaCl、150 mm 咪唑、0.1 mM PMSF、0.2 mm DTT、25% 甘油中提供。
Legal Information
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
警示词
Danger
危险代码
Hazard Classifications
Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
怎么回事?
WGK 1
闪点 (F)
Not applicable
闪点 (°C)
Not applicable
PPE(个人防护设备)
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

