G4391
Gly-Arg-Gly-Asp-Ser
≥97% (HPLC)
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关于此项目
经验公式（希尔记法）:
C17H30N8O9
化学文摘社编号:
分子量:
490.47
MDL编号:
UNSPSC代码:
12352209
PubChem化学物质编号:
NACRES:
NA.32
质量水平
方案
≥97% (HPLC)
表单
powder
组成
Peptide content, ≥60%
技术
blocking: suitable
cell culture | mammalian: suitable
储存温度
−20°C
SMILES字符串
NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(O)=O
InChI
1S/C17H30N8O9/c18-5-11(27)23-8(2-1-3-21-17(19)20)14(31)22-6-12(28)24-9(4-13(29)30)15(32)25-10(7-26)16(33)34/h8-10,26H,1-7,18H2,(H,22,31)(H,23,27)(H,24,28)(H,25,32)(H,29,30)(H,33,34)(H4,19,20,21)/t8-,9-,10-/m0/s1
InChI key
RGNVSYKVCGAEHK-GUBZILKMSA-N
基因信息
human ... ITGB3(3690)
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Amino Acid Sequence
Gly-Arg-Gly-Asp-Ser
一般描述
Gly-Arg-Gly-Asp-Ser 肽序列与纤连蛋白的细胞结合区相同。Arg-Gly-Asp（RGD）区存在于各种蛋白质中，对促进细胞粘附活性很重要。
应用
Gly-Arg-Gly-Asp-Ser 已用于-
- 作为抗原，用在小鼠中确定整合素 α4 或 α5 是否阻碍照射后第 3 天胸腺细胞与胸腺上皮细胞的粘附
- 处理胶原蛋白 IV 包被的培养皿，研究整联蛋白 α1, αv、β1 和 β3 在 Sca-1+ 祖细胞分化为 SMC（平滑肌细胞）中的作用
- 作为脑膜炎奈瑟菌菌株预培养的封闭肽，用于进行研究这些细菌菌株与纤连蛋白之间的相互作用的封闭实验
- 预处理 AdCMV-GFP（巨细胞病毒-绿色荧光蛋白）感染的 EL-4 细胞，研究与细胞整联蛋白的相互作用对于腺病毒的转导是否是必需的
生化/生理作用
当与 B16-F10 黑色素瘤细胞共同注射时，Gly-Arg-Gly-Asp-Ser 抑制同系小鼠或缺乏血小板功能的小鼠的肿瘤转移。
整联蛋白功能拮抗剂
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
T Eberhard et al.
Infection and immunity, 66(4), 1791-1794 (1998-04-07)
Adhesion of Neisseria meningitidis strains to extracellular matrix (ECM) and purified matrix components was examined. Most strains bound to subendothelial ECM as well as to immobilized fibronectin and types I, III, and V collagen. Strains from healthy carriers adhered significantly
PCL-PEG-based nanoparticles grafted with GRGDS peptide: preparation and surface analysis by XPS.
Vincent Pourcelle et al.
Biomacromolecules, 8(12), 3977-3983 (2007-11-28)
Yves Lecarpentier et al.
PloS one, 14(10), e0222683-e0222683 (2019-10-02)
Mesenchymal stem cells (MSCs) were obtained from human bone marrow and amplified in cultures supplemented with human platelet lysate in order to generate myofibroblasts. When MSCs were seeded in solid collagen scaffolds, they differentiated into myofibroblasts that were observed to
I Saiki et al.
British journal of cancer, 60(5), 722-728 (1989-11-01)
We have investigated the inhibitory effect on experimental or spontaneous lung metastases of polypeptides which contain repetitive structures of the Arg-Gly-Asp (RGD) or Tyr-Ile-Gly-Ser-Arg (YIGSR) sequence derived from adhesion molecules, and studied their biological characterisation after administration. In the spontaneous
Virginie Fievez et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 73(1), 16-24 (2009-05-05)
The presence of RGD on nanoparticles allows the targeting of beta1 integrins at the apical surface of human M cells and the enhancement of an immune response after oral immunization. To check the hypothesis that non-peptidic ligands targeting intestinal M
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