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Merck
CN

G4401

鸟苷 5′-二磷酸-β- L -岩藻糖 钠盐

≥85%, powder

别名:

6-脱氧-β- L -半乳吡喃糖基鸟苷 5′-二磷酸, GDP-Fuc, GDP-海藻糖

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关于此项目

经验公式(希尔记法):
C16H23N5Na2O15P2
化学文摘社编号:
分子量:
633.31
UNSPSC Code:
12352204
PubChem Substance ID:
NACRES:
NA.32
MDL number:
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产品名称

鸟苷 5′-二磷酸-β- L -岩藻糖 钠盐, ≥85%

SMILES string

CC1OC(OP(O)(=O)OP(O)(=O)OCC2OC(C(O)C2O)n3cnc4C(=O)N=C(N)Nc34)C(O)C(O)C1O

InChI

1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)

InChI key

LQEBEXMHBLQMDB-UHFFFAOYSA-N

assay

≥85%

form

powder

solubility

water: 50 mg/mL, clear, colorless to faintly yellow

storage temp.

−20°C

Quality Level

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General description

岩藻糖基转移酶底物
鸟苷5′-二磷酸-β-L-岩藻糖(GDP-岩藻糖)是存在于细菌和人类中的一种核苷酸糖,也是岩藻糖基转移酶的底物。

Application

鸟苷5′-二磷酸-β-L-岩藻糖钠盐可用作岩藻糖基转移酶VII(FTVII)反应缓冲液组分,用于鼠脂肪组织来源间充质干细胞(AMSC)的胞外岩藻糖基化。它已用于微生物凝集试验和凝集抑制试验。
鸟苷5′-二磷酸-β-L-岩藻糖钠盐已用于微生物凝集试验和凝集抑制试验。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

涉药品监管产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Stephen T B Lau et al.
Journal of the American Chemical Society, 130(51), 17593-17602 (2008-12-05)
L-fucose, 6-deoxy-L-galactose, is a key component of many important glycoconjugates including the blood group antigens and the Lewis(X) ligands. The biosynthesis of GDP-L-fucose begins with the action of a dehydratase that converts GDP-D-mannose into GDP-4-keto-6-deoxy-mannose. The enzyme GDP-fucose synthase, GFS
Qiang Yang et al.
The Journal of biological chemistry, 292(36), 14796-14803 (2017-07-22)
The mammalian α1,6-fucosyltransferase (FUT8) catalyzes the core fucosylation of
Qiong Wang et al.
Biotechnology and bioengineering, 115(6), 1378-1393 (2018-02-20)
As a key parameter impacting functional and structural heterogeneity, protein glycosylation is a critical quality attribute for antibody biotherapeutic manufacturing. The glycan patterns on recombinant antibodies, particularly on the conserved fragment crystallizable (Fc) region, can have significant effects on an
Erandi Lira-Navarrete et al.
PloS one, 6(9), e25365-e25365 (2011-10-04)
Protein O-fucosylation is an essential post-translational modification, involved in the folding of target proteins and in the role of these target proteins during embryonic development and adult tissue homeostasis, among other things. Two different enzymes are responsible for this modification
Diego Sánchez-Martínez et al.
Clinical and translational medicine, 11(2), e280-e280 (2021-02-27)
CD19-directed chimeric antigen receptors (CAR) T cells induce impressive rates of complete response in advanced B-cell malignancies, specially in B-cell acute lymphoblastic leukemia (B-ALL). However, CAR T-cell-treated patients eventually progress due to poor CAR T-cell persistence and/or disease relapse. The

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