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Merck
CN

G4635

芰皂配基

别名:

16β-Hydroxydigitoxigenin, 3β,14,16β,21-Tetrahydroxy-20(22)-norcholenic acid lactone, 3β,14,16β-Trihydroxy-5β,20(22)-cardenolide, 5β,20(22)-Cardenolide-3β,14,16β-triol

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关于此项目

经验公式(希尔记法):
C23H34O5
化学文摘社编号:
分子量:
390.51
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
208-886-2
MDL number:
Beilstein/REAXYS Number:
96483
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storage temp.

−20°C

SMILES string

[H][C@]12CC[C@]3([H])[C@]([H])(CC[C@]4(C)[C@H]([C@@H](O)C[C@]34O)C5=CC(=O)OC5)[C@@]1(C)CC[C@H](O)C2

Biochem/physiol Actions

Structure-activity relationships for 16β-substituted digitoxigenins as inhibitors of Na+/K+ ATPases.

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Skull and crossbones

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Tomonori Arao et al.
Journal of analytical toxicology, 26(4), 222-227 (2002-06-11)
Simultaneous determination of oleandrin and its three related compounds, desacetyloleandrin, oleandrigenin, and gitoxigenin in blood by using liquid chromatography-three-dimensional quadrupole mass spectrometry (LC-3DQMS) system equipped with sonic spray ionization (SSI) interface was conducted. This analyzing method was suitable for all
Miguel López-Lázaro et al.
Planta medica, 69(8), 701-704 (2003-10-08)
Recent research has shown the anticancer effects of digitalis compounds suggesting their possible use in medical oncology. Four extracts obtained from the leaves of Digitalis purpurea subsp. heywoodii have been assessed for cytotoxic activity against three human cancer cell lines
Jack T Rogers et al.
Journal of neural transmission (Vienna, Austria : 1996), 118(3), 493-507 (2011-01-12)
Increased brain α-synuclein (SNCA) protein expression resulting from gene duplication and triplication can cause a familial form of Parkinson's disease (PD). Dopaminergic neurons exhibit elevated iron levels that can accelerate toxic SNCA fibril formation. Examinations of human post mortem brain
Rupali Dhara et al.
Journal of oleo science, 59(4), 169-176 (2010-03-20)
The amount and characterization of phytosterol and other minor components present in three Indian minor seed oils, mahua (Madhuca latifolia), sal (Shorea robusta) and mango kernel (Mangifera indica), have been done. Theses oils have shown commercial importance as cocoa-butter substitutes
Miguel López-Lázaro et al.
Journal of natural products, 68(11), 1642-1645 (2005-11-29)
The cardiac glycosides digitoxin (1) and digoxin (3) have been used in cardiac diseases for many years. During this time several reports have suggested the possible use of digitalis in medical oncology. Several analogues of digitoxin (1) were evaluated for

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