G5048
替普瑞酮(异构体混合物)
别名:
6,10,14,18-四甲基-5,9,13,17-十九碳四烯-2-酮，(5E,9E,13E)和(5Z,9E,13E)异构体混合物, GGA, UNII-S8S8451A4O, 戊四烯酮, 替普瑞酮
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关于此项目
经验公式（希尔记法）:
C23H38O
化学文摘社编号:
分子量:
330.55
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI
1S/C23H38O/c1-19(2)11-7-12-20(3)13-8-14-21(4)15-9-16-22(5)17-10-18-23(6)24/h11,13,15,17H,7-10,12,14,16,18H2,1-6H3/b20-13+,21-15+,22-17+
SMILES string
C\C(C)=C\CC\C(C)=C\CC\C(C)=C\CC\C(C)=C\CCC(C)=O
InChI key
HUCXKZBETONXFO-NJFMWZAGSA-N
assay
≥98% (HPLC)
form
oil
storage condition
protect from light
color
clear
solubility
DMSO: >5 mg/mL
storage temp.
−20°C
Quality Level
Application
替普瑞酮已被用作热休克蛋白70 (HSP70)的诱导剂，以分析对局部缺血/再灌注(I/R)的保护作用。
Biochem/physiol Actions
替普瑞酮可以诱导 HSP70、HSPB8 和 HSPB1 的表达。
替普瑞酮可以诱导 HSP70、HSPB8 和 HSPB1 的表达。诱导 HSP70 表达可预防各种疾病的发展，例如炎症性肠病、缺氧/缺血性脑损伤，以及脊髓和延髓性肌萎缩（细胞保护和抗炎作用）。 报告表明，GGA 可通过诱导 HSP70 表达来预防 NSAID 诱导的胃和肠损伤。其他研究表明，GGA 可以诱导 HSPB5 R120G TG 小鼠中 HSPB8 和 HSPB1 的表达，并减少淀粉样蛋白低聚物以及不溶性聚集体的形成。
替普瑞酮是一种无环聚异戊二烯类化合物，研究表明对再灌注损伤、炎症和器官移植具有保护作用。它是一种抗溃疡剂，参与保护胃黏膜。
存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Noritaka Fujimura et al.
Arteriosclerosis, thrombosis, and vascular biology, 32(1), 153-160 (2011-10-15)
Geranylgeranylacetone (GGA) induces expression of heat shock protein 90 (Hsp90), an adaptor molecule for assembly of endothelial nitric oxide synthase (eNOS) phosphorylation complex. The purpose of this study was to determine whether GGA enhances Hsp90 expression and augments endothelium-dependent vasodilation
Kylie Kavanagh et al.
American journal of physiology. Endocrinology and metabolism, 300(5), E894-E901 (2011-02-18)
We evaluated heat shock protein 70 (HSP70) changes in diabetes mellitus (DM) in a nonhuman primate model. To this end, two studies were conducted in DM vervet monkeys. 1) Normal control and streptozotocin-induced DM monkeys (Stz-DM) that were differentiated into
Yoko Ishii et al.
Investigative ophthalmology & visual science, 44(5), 1982-1992 (2003-04-26)
To study the effects of geranylgeranylacetone (GGA) on the expression of inducible (HSP72) and constitutive (HSC70) heat shock proteins (HSPs) on retinal ganglion cells (RGCs) in a rat model of glaucoma. Adult Wistar rats were given intraperitoneal injections of GGA
Geranylgeranylacetone suppresses hydrogen peroxide-induced apoptosis of osteoarthritic chondrocytes.
Masaki Yoda et al.
Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 16(6), 791-798 (2011-08-13)
Osteoarthritis (OA) is a common disease, afflicting many sufferers with both pain and functional disorders. Various therapies have been attempted for OA, but no fully effective treatment has been established yet. Apoptosis of chondrocytes caused by reactive oxygen species (ROS)
Michio Hongo et al.
Journal of gastroenterology and hepatology, 27(1), 62-68 (2011-10-19)
Functional dyspepsia (FD) is a common condition seen in primary gastroenterology practice. The present study was conducted to compare the clinical effectiveness of mosapride and teprenone in patients with FD. Prospective clinical comparative study with random allocation of open labeled
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