G5149
Gly-Gln 一水合物
≥97% (HPLC), powder
别名:
甘氨酰-L-谷氨酰胺
登录查看公司和协议定价
选择尺寸
关于此项目
经验公式（希尔记法）:
C7H13N3O4 · H2O
化学文摘社编号:
分子量:
221.21
MDL编号:
UNSPSC代码:
12352209
PubChem化学物质编号:
NACRES:
NA.32
Amino Acid Sequence
Gly-Gln
一般描述
甘氨酰谷氨酰胺(Glycyl-glutamine)是L-谷氨酰胺的二肽形式。甘谷二肽具有较高的溶解性和热稳定性。静脉输液后可快速水解为谷氨酰胺和甘氨酸。甘氨酸通过防止细胞膜渗漏来保护心肌细胞免遭缺血性损伤。此外，补充甘谷二肽还有利于大鼠的心肌保护，因为它能增强心肌细胞的能量代谢以及ATP和谷胱甘肽合成。
甘氨酰谷氨酰胺（gly-gln）是一种二肽，在细胞培养中用作谷氨酰胺的替代物。当使用该二肽代替谷氨酰胺时，由于 gly-gln 影响底物利用和代谢，可获得更高的细胞产量。由于较低的肽酶亲和力，该二肽的浓度维持很高，细胞生长较快。
应用
甘谷二肽单水合物已用于：
- 作为杜氏改良Eagle培养基(DMEM)补充剂，用于培养马胚胎
- 作为DMEM/F-12补充剂，用于培养卵裂期马胚胎
- 加入人输卵管液(HTF)，以研究市售胚胎培养基在培养和储存中的铵积聚
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Ammonium accumulation in commercially available embryo culture media and protein supplements during storage at 2-8 C and during incubation at 37 C
Kleijkers SHM, et al.
Human Reproduction, 31, 1192-1199 (2016)
A Christie et al.
Journal of biotechnology, 37(3), 277-290 (1994-11-15)
A murine hybridoma (CC9C10) was grown in media containing alanyl-glutamine (ala-gln) or glycyl-glutamine (gly-gln) as a substitute for glutamine. High cell yields were obtained in the presence of 6 mM ala-gln or 20 mM gly-gln. The final cell yield in
Culture protocols for horse embryos after ICSI: Effect of myo-inositol and time of media change
Brom-de-Luna JG, et al.
Animal Reproduction Science, 233, 106819-106819 (2021)
D C Parish et al.
Nature, 306(5940), 267-270 (1983-11-17)
The primary mechanism of activation of intracellular prohormones seems to involve proteolytic cleavage at sequences of consecutive basic residues. Thus, all the known biologically active peptides derived from the prohormone of corticotropin and beta-endorphin appear to be excised initially by
Sander H M Kleijkers et al.
Human reproduction (Oxford, England), 31(6), 1192-1199 (2016-04-08)
Does ammonium accumulate in commercially available culture media and protein supplements used for in vitro development of human pre-implantation embryos during storage and incubation? Ammonium accumulates in ready-to-use in vitro fertilization (IVF) culture media during storage at 2-8°C and in
商品
L-谷氨酰胺在杂交瘤细胞和哺乳动物细胞培养中的重要性和应用
Importance and uses of glutamine in hybridoma and mammalian cell culture
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持