G5149
Gly-Gln 一水合物
≥97% (HPLC), powder
别名:
甘氨酰-L-谷氨酰胺
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关于此项目
经验公式（希尔记法）:
C7H13N3O4 · H2O
化学文摘社编号:
分子量:
221.21
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.32
MDL number:
Assay:
≥97% (HPLC)
Quality level:
产品名称
Gly-Gln 一水合物, ≥97% (HPLC)
SMILES string
O.NCC(=O)N[C@@H](CCC(N)=O)C(O)=O
InChI key
KLFWVRQACSYLOH-WCCKRBBISA-N
InChI
1S/C7H13N3O4.H2O/c8-3-6(12)10-4(7(13)14)1-2-5(9)11;/h4H,1-3,8H2,(H2,9,11)(H,10,12)(H,13,14);1H2/t4-;/m0./s1
assay
≥97% (HPLC)
storage temp.
−20°C
Quality Level
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相关类别
Application
甘谷二肽单水合物已用于：
- 作为杜氏改良Eagle培养基(DMEM)补充剂，用于培养马胚胎
- 作为DMEM/F-12补充剂，用于培养卵裂期马胚胎
- 加入人输卵管液(HTF)，以研究市售胚胎培养基在培养和储存中的铵积聚
General description
甘氨酰谷氨酰胺(Glycyl-glutamine)是L-谷氨酰胺的二肽形式。甘谷二肽具有较高的溶解性和热稳定性。静脉输液后可快速水解为谷氨酰胺和甘氨酸。甘氨酸通过防止细胞膜渗漏来保护心肌细胞免遭缺血性损伤。此外，补充甘谷二肽还有利于大鼠的心肌保护，因为它能增强心肌细胞的能量代谢以及ATP和谷胱甘肽合成。
甘氨酰谷氨酰胺（gly-gln）是一种二肽，在细胞培养中用作谷氨酰胺的替代物。当使用该二肽代替谷氨酰胺时，由于 gly-gln 影响底物利用和代谢，可获得更高的细胞产量。由于较低的肽酶亲和力，该二肽的浓度维持很高，细胞生长较快。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Effects of glycyl-glutamine dipeptide supplementation on myocardial damage and cardiac function in rats after severe burn injury
Zhang Y, et al.
International Journal of Clinical and Experimental Pathology, 6, 821-821 (2013)
Culture protocols for horse embryos after ICSI: Effect of myo-inositol and time of media change
Brom-de-Luna JG, et al.
Animal Reproduction Science, 233, 106819-106819 (2021)
Parish, D.C. and Smyth, D.G.
Biochemical Society Transactions, 10, 221-221 (1982)
Ammonium accumulation in commercially available embryo culture media and protein supplements during storage at 2-8 C and during incubation at 37 C
Kleijkers SHM, et al.
Human Reproduction, 31, 1192-1199 (2016)
D C Parish et al.
Nature, 306(5940), 267-270 (1983-11-17)
The primary mechanism of activation of intracellular prohormones seems to involve proteolytic cleavage at sequences of consecutive basic residues. Thus, all the known biologically active peptides derived from the prohormone of corticotropin and beta-endorphin appear to be excised initially by
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