G5422
β-甘油磷酸盐 二钠盐 水合物
≤1.0 mol % L-α-isomer
别名:
BGP, 甘油2-磷酸酯 二钠盐 水合物
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关于此项目
线性分子式:
(HOCH2)2CHOP(O)(ONa)2 · xH2O
化学文摘社编号:
分子量:
216.04 (anhydrous basis)
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352201
EC Number:
212-464-3
MDL number:
InChI
1S/C3H9O6P.2Na.H2O/c4-1-3(2-5)9-10(6,7)8;;;/h3-5H,1-2H2,(H2,6,7,8);;;1H2/q;2*+1;/p-2
InChI key
ROPZSVKNEIIIDE-UHFFFAOYSA-L
SMILES string
O.[Na+].[Na+].OCC(CO)OP([O-])([O-])=O
biological source
synthetic
form
powder
impurities
≤0.1% Inorganic phosphorus, ≤1.0 mol % L-α-isomer
mp
102-104 °C (lit.)
solubility
water: 50 mg/mL, clear, colorless
Quality Level
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Application
β-甘油磷酸盐是激酶反应缓冲液中丝氨酸-苏氨酸磷酸酶的一种经典抑制剂。BGP通常与其他磷酸酶/蛋白酶抑制剂组合，以实现广谱抑制。它可用作有机磷酸盐供体，并且已用于使间充质干细胞分化为成骨细胞型细胞的培养基。BGP也用于缓冲乳酸菌的M17培养基，以进行重组蛋白表达。
β-甘油磷酸盐用于固定后肌肉提取物的均质化溶液。
对嵌入天然胶原/壳聚糖凝胶（用于组织工程）中的骨髓衍生干细胞进行诱导分化。
Analysis Note
低无机磷酸盐含量。α-和β-甘油磷酸盐的混合物长期以来用于微生物的培养基中，但高水平的无机（游离）磷酸盐与细菌和不需要的沉淀物的不规则生长有关。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Morten Donsmark et al.
The Journal of physiology, 550(Pt 3), 845-854 (2003-06-10)
Intramuscular triacylglycerol is an important energy store and is also related to insulin resistance. The mobilization of fatty acids from this pool is probably regulated by hormone-sensitive lipase (HSL), which has recently been shown to exist in muscle and to
Yang An et al.
Biochemical and biophysical research communications, 516(2), 551-557 (2019-06-27)
Developing methods for regenerating bones and uncovering the molecular mechanism underlying bone formation have great significance to human health. In the last decade, people have been using adipose-derived stem cells (ADSCs), that are capable of multilineage differentiation, to reconstruct defected
J Douglas et al.
The Journal of applied bacteriology, 56(2), 321-326 (1984-04-01)
An easily prepared medium, originally designed for the cultivation of lactic phages, has been found to have much wider application. Experience in its use over a ten year period with a range of physiologically diverse bacteria, for teaching and research
Harvey W Smith et al.
Proceedings of the National Academy of Sciences of the United States of America, 117(33), 20139-20148 (2020-07-31)
Lung cancer causes more deaths annually than any other malignancy. A subset of non-small cell lung cancer (NSCLC) is driven by amplification and overexpression or activating mutation of the receptor tyrosine kinase (RTK) ERBB2 In some contexts, notably breast cancer
Lucas R Brun et al.
SpringerPlus, 3, 676-676 (2014-12-19)
The aim of this study was to evaluate the effect of strontium ranelate (SrR) on bone mineral density (BMD) and bone turnover markers after 1 year of treatment. Additionally, the effect of SrR in bisphosphonate-naïve patients (BP-naïve) compared to patients previously
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