G5642
Monosialoganglioside GM₃
from canine blood, ≥98%, epidermal cell growth inhibitor, lyophilized powder
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Assay:
≥98%
Form:
lyophilized powder
产品名称
Monosialoganglioside GM3 from canine blood, ≥98%, lyophilized powder
Quality Segment
assay
≥98%
form
lyophilized powder
solubility
chloroform/methanol/water (9.5:9.5:1): 20 mg/mL, clear, colorless to light yellow
storage temp.
−20°C
General description
Gangliosides are major constituents of neuronal cell membranes and endoplasmic reticulum. They contain a sialated polysaccharide chain linked to ceramide through a β-glycosidic linkage. For classification of gangliosides see Svennerholm, L., et al. (eds.), Structure and Function of Gangliosides, New York, Plenum, 1980.
Application
Monosialoganglioside GM3 from canine blood has been used as a reference standard in high-performance thin-layer chromatography (HPTLC) to analyze ganglioside signatures of prostate cancer (CaP) cells. It has also been used to determine ganglioside-binding profiles of methylotrophic yeast (Pichia pastoris) secreted cholera toxin B subunit (PpCTB) by enzyme-linked immunosorbent assay (ELISA).
Biochem/physiol Actions
Monosialoganglioside GM3 has a potential role in cancer development and progression. Increased expression of GM3 has been observed in various types of cancer. Hence, it is used as a tumor-associated carbohydrate antigen during cancer vaccine development.
Monosialoganglioside-GM3 is the most common ganglioside and the major ganglioside in non-neuronal cell membranes. It inhibits epidermal cell growth and is involved in the biosynthesis and metabolism of all higher gangliosides.
Analysis Note
The product is soluble at 20 mg/mL in a 1:1 mixture of chloroform and ethanol with 5% water. The resulting solution is colorless
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)