G6264
鸟苷
BioReagent, suitable for cell culture
别名:
9-(β-D-呋喃核糖基)鸟嘌呤, 鸟嘌呤-9-β-D-呋喃核糖苷
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选择尺寸
关于此项目
经验公式（希尔记法）:
C10H13N5O5
化学文摘社编号:
分子量:
283.24
PubChem Substance ID:
UNSPSC Code:
12352205
MDL number:
NACRES:
NA.75
EC Number:
204-227-8
Beilstein/REAXYS Number:
625911
产品名称
鸟苷, BioReagent, suitable for cell culture
InChI key
NYHBQMYGNKIUIF-UUOKFMHZSA-N
InChI
1S/C10H13N5O5/c11-10-13-7-4(8(19)14-10)12-2-15(7)9-6(18)5(17)3(1-16)20-9/h2-3,5-6,9,16-18H,1H2,(H3,11,13,14,19)/t3-,5-,6-,9-/m1/s1
SMILES string
[H]O[H].NC1=Nc2c(ncn2[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)C(=O)N1
biological source
synthetic
product line
BioReagent
assay
≥98%
form
powder
technique(s)
cell culture | mammalian: suitable
mp
250 °C (dec.) (lit.)
solubility
0.05 M acetic acid: 1 mg/mL, clear, colorless
shipped in
ambient
storage temp.
room temp
Quality Level
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Application
鸟苷已用作：
- 作为基础培养基的核糖核苷组分，研究其对莫哈韦芽胞杆菌厌氧生长的影响
- 作为杜氏改良Eagle培养基（DMEM）的组分，用于培养小鼠来源的胚胎干细胞
- 作为核苷溶液的组分，用于培养鸡胚胎干细胞
Biochem/physiol Actions
鸟苷是一种在细胞代谢中起重要作用的嘌呤核苷。通过诱导增殖分化和抗凋亡作用，它在神经胶质细胞、海马神经元、嗜铬细胞瘤细胞中也表现出神经保护和神经营养作用。鸟苷可作为药物治疗多种神经疾病。它对败血症诱导的认知障碍、肝性脑病、脂多糖（LPS）诱导的炎症、缺血性损伤和叠氮化物诱导的氧化损伤有效果。鸟苷适用于细胞培养应用，作为一磷酸鸟苷（GMP）、二磷酸鸟苷（GDP）、三磷酸鸟苷（GTP）和环GMP（cGMP）的前体。
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Jeffery T Davis et al.
Chemical Society reviews, 36(2), 296-313 (2007-02-01)
Nature's use of a simple genetic code to enable life's complex functions is an inspiration for supramolecular chemistry. DNA nucleobases carry the key information utilizing a variety of cooperative and non-covalent interactions such as hydrophobic, van der Waals, pi-pi stacking
Zoran D Matović et al.
Journal of inorganic biochemistry, 121, 134-144 (2013-02-05)
Novel square-planar palladium(II) complexes with O-N-N-O-type ligands H4mda (H4mda=malamido-N,N'-diacetic acid) and H4obp (H4obp=oxamido-N,N'-di-3-propionic acid) were prepared and characterized. The ligands coordinate to the palladium(II) ion via two pairs of deprotonated ligating atoms with square chelation. A four coordinate, square-planar geometry
Nadine Gehrke et al.
Immunity, 39(3), 482-495 (2013-09-03)
Immune sensing of DNA is critical for antiviral immunity but can also trigger autoimmune diseases such as lupus erythematosus (LE). Here we have provided evidence for the involvement of a damage-associated DNA modification in the detection of cytosolic DNA. The oxidized base
Aditya C Bandekar et al.
Current biology : CB, 30(20), 3961-3971 (2020-09-12)
Although the major events in prokaryotic cell cycle progression are likely to be coordinated with transcriptional and metabolic changes, these processes remain poorly characterized. Unlike many rapidly growing bacteria, DNA replication and cell division are temporally resolved in mycobacteria, making
Thomas Gonatopoulos-Pournatzis et al.
The Biochemical journal, 457(2), 231-242 (2013-12-21)
The 7mG (7-methylguanosine cap) formed on mRNA is fundamental to eukaryotic gene expression. Protein complexes recruited to 7mG mediate key processing events throughout the lifetime of the transcript. One of the most important mediators of 7mG functions is CBC (cap-binding
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