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Merck
CN

G7132

甘胆酸钠 水合物

≥95% (TLC)

别名:

3α,7α,12α-三羟基-5β-胆烷-24-酸 N-（羧甲基）酰胺 钠盐, N-（3α,7α,12α-三羟基-24-氧代胆碱-24-基）甘氨酸 钠盐, 甘氨胆酸 钠盐, 甘氨胆酸 钠盐 水合物

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关于此项目

线性分子式:
C26H42NO6Na · xH2O
化学文摘社编号:
338950-81-5
分子量:
487.60 (anhydrous basis)
UNSPSC Code:
12161900
NACRES:
NA.25
PubChem Substance ID:
24895292
EC Number:
212-730-9
Beilstein/REAXYS Number:
3854517
MDL number:
MFCD09037360

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产品名称

甘胆酸钠 水合物, ≥95% (TLC)

InChI key

YWROUPFMHKARON-HJRQWJHVSA-M

InChI

1S/C26H43NO6.Na.H2O/c1-14(4-7-22(31)27-13-23(32)33)17-5-6-18-24-19(12-21(30)26(17,18)3)25(2)9-8-16(28)10-15(25)11-20(24)29;;/h14-21,24,28-30H,4-13H2,1-3H3,(H,27,31)(H,32,33);;1H2/q;+1;/p-1/t14-,15+,16-,17-,18+,19+,20-,21+,24+,25+,26-;;/m1../s1

SMILES string

[Na+].[H]O[H].[H][C@@]12C[C@H](O)CC[C@]1(C)[C@@]3([H])C[C@H](O)[C@]4(C)[C@H](CC[C@@]4([H])[C@]3([H])[C@H](O)C2)[C@H](C)CCC(=O)NCC([O-])=O

description

anionic

assay

≥95% (TLC)

mol wt

micellar avg mol wt 900(lit.)

aggregation number

1.9

CMC

13 mM (20-25°C)(lit.)

mp

210-215 °C (subl.) (lit.)

Quality Level

200

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相关类别

Application

在一项研究中，使用甘胆酸钠水合物通过荧光法和酶法评估血清总胆汁酸。 也用于研究其对睾酮胶束形成和增溶的影响。

Biochem/physiol Actions

胆盐

General description

甘胆酸钠水合物是一种共轭胆盐和离子型生物洗涤剂。

Preparation Note

该产品由天然胆酸（产品号C1129）合成制备而成。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000522152
0000522151
0000522152
0000522151
0000522154

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Mari Araki et al.
Journal of biochemistry, 160(5), 269-279 (2016-11-02)
DDHD2 has been reported to exhibit phospholipase A
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Colloids and surfaces. B, Biointerfaces, 170, 521-528 (2018-07-04)
Poorly soluble vitamin K cannot be absorbed by patients suffering from cholestasis due to extremely low level of bile salts in the intestine. A formulation of vitamin K including glycocholic acid (i.e. Konakion® MM), does not increase bioavailability because it
Micelle formation and testosterone solubilization by sodium glycocholate.
L Martis et al.
Journal of pharmaceutical sciences, 61(11), 1757-1761 (1972-11-01)
Monalisa Mohapatra et al.
Langmuir : the ACS journal of surfaces and colloids, 27(22), 13461-13467 (2011-10-07)
The interaction of submicellar concentrations of various physiologically important unconjugated [sodium deoxycholate (NaDC), sodium cholate (NaC)] and conjugated [sodium glycodeoxycholate (NaGDC), sodium glycocholate (NaGC), sodium taurodeoxycholate (NaTDC), sodium taurocholate (NaTC)] bile salts with dipalmitoylphosphatidylcholine (DPPC) and dimyristoylphosphatidylcholine (DMPC) small unilamellar
Robert Creutznacher et al.
Chembiochem : a European journal of chemical biology, 21(7), 1007-1021 (2019-10-24)
Bile acids have been reported as important cofactors promoting human and murine norovirus (NoV) infections in cell culture. The underlying mechanisms are not resolved. Through the use of chemical shift perturbation (CSP) NMR experiments, we identified a low-affinity bile acid
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