G7504
鸟苷 3′,5′-环单磷酸
≥98% (HPLC), powder, intracellular mediator
别名:
环化鸟嘌呤核苷酸, 环鸟苷酸
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经验公式（希尔记法）:
C10H12N5O7P
化学文摘社编号:
分子量:
345.21
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
41106305
EC Number:
231-641-6
MDL number:
产品名称
鸟苷 3′,5′-环单磷酸, ≥98% (HPLC), powder
InChI key
ZOOGRGPOEVQQDX-UHFFFAOYSA-N
InChI
1S/C10H12N5O7P/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6-3(21-9)1-20-23(18,19)22-6/h2-3,5-6,9,16H,1H2,(H,18,19)(H3,11,13,14,17)
SMILES string
NC1=NC(=O)c2ncn(C3OC4COP(O)(=O)OC4C3O)c2N1
assay
≥98% (HPLC)
form
powder
color
white
solubility
0.2 M NaHCO3: 50 mg/mL
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
作为一种重要的第二信使，cGMP 是细胞外信号（如一氧化氮和利钠肽）的主要细胞内介质。环 GMP 与三种类型的细胞内受体蛋白相互作用：cGMP 依赖性蛋白激酶、cGMP 调节的通道和 cGMP 调节的环核苷酸磷酸二酯酶。体内 cGMP 水平升高的主要作用是刺激 cGMP 依赖性蛋白激酶 (PKG)。
细胞外信号的主要细胞内介质，如一氧化氮和利钠肽。
Features and Benefits
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Nature, 504(7480), 432-436 (2013-11-12)
Myocardial infarction, a leading cause of death in the Western world, usually occurs when the fibrous cap overlying an atherosclerotic plaque in a coronary artery ruptures. The resulting exposure of blood to the atherosclerotic material then triggers thrombus formation, which
Juliane W Schott et al.
Molecular therapy. Methods & clinical development, 14, 134-147 (2019-07-25)
Ex vivo retroviral gene transfer into CD34+ hematopoietic stem and progenitor cells (HSPCs) has demonstrated remarkable clinical success in gene therapy for monogenic hematopoietic disorders. However, little attention has been paid to enhancement of culture and transduction conditions to achieve reliable
Ko-Hsin Chin et al.
Acta crystallographica. Section D, Biological crystallography, 69(Pt 3), 352-366 (2013-03-23)
The mammalian ER protein STING (stimulator of interferon genes; also known as MITA, ERIS, MPYS or TMEM173) is an adaptor protein that links the detection of cytosolic dsDNA to the activation of TANK-binding kinase 1 (TBK1) and its downstream transcription
Aging Influences Hepatic Microvascular Biology and Liver Fibrosis in Advanced Chronic Liver Disease.
Raquel Maeso-Díaz et al.
Aging and disease, 10(4), 684-698 (2019-08-24)
Advanced chronic liver disease (aCLD) represents a major public health concern. aCLD is more prevalent and severe in the elderly, carrying a higher risk of decompensation. We aimed at understanding how aging may impact on the pathophysiology of aCLD in
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Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
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