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关于此项目
经验公式(希尔记法):
C21H15N5O3S2
化学文摘社编号:
分子量:
449.51
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:
产品名称
GW8510, solid
InChI
1S/C21H15N5O3S2/c27-21-15(19-16(25-21)8-9-17-20(19)30-12-24-17)11-23-13-4-6-14(7-5-13)31(28,29)26-18-3-1-2-10-22-18/h1-12,23H,(H,22,26)(H,25,27)/b15-11-
SMILES string
O=C1Nc2ccc3ncsc3c2\C1=C\Nc4ccc(cc4)S(=O)(=O)Nc5ccccn5
InChI key
GCYXEGSPUDSZJY-PTNGSMBKSA-N
assay
~98% (HPLC)
form
solid
solubility
DMSO: soluble
storage temp.
room temp
Quality Level
Gene Information
human ... CDC2(983), CDK2(1017)
Biochem/physiol Actions
最初作为细胞周期蛋白依赖性激酶 2(CDK2)的抑制剂,随后的研究表明 GW8510 是非选择性的。
Legal Information
根据葛兰素史克的协议出售,用于研究目的
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Ping Chen et al.
Clinical science (London, England : 1979), 132(13), 1417-1433 (2018-06-02)
Although chemotherapeutic regimen containing gemcitabine is the first-line therapy for advanced lung squamous cell carcinoma (LSCC), gemcitabine resistance remains an important clinical problem. Some studies suggest that overexpressions of ribonucleotide reductase (RNR) subunit M2 (RRM2) may be involved in gemcitabine
Kayode K Ojo et al.
Antimicrobial agents and chemotherapy, 52(10), 3710-3717 (2008-07-23)
Development of a safe, effective, and inexpensive therapy for African trypanosomiasis is an urgent priority. In this study, we evaluated the validity of Trypanosoma brucei glycogen synthase kinase 3 (GSK-3) as a potential drug target. Interference with the RNA of
Narisa Chan et al.
Scientific reports, 5, 11777-11777 (2015-07-01)
The cytoplasmic mutant of nucleophosmin (NPMc) is found approximately in one-third of acute myeloid leukemia (AML) cases and is highly associated with normal karyotype. Whereas previous studies have focused on wtNPM in centrosome duplication, we further elucidate the role of
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