G8255
谷丙转氨酶 来源于猪心脏
lyophilized powder, ≥75 units/mg protein
别名:
L-丙氨酸:2-酮戊二酸氨基转移酶, GPT, 丙氨酸氨基转移酶（催化浓度）
一般描述
谷丙转氨酶（GPT）主要分布于肝脏。
研究领域：细胞信号传导
研究领域：细胞信号传导
应用
猪心谷丙转氨酶已用于：
- 检测其对人工合成的3-甲基-2-酮戊二酸外消旋混合物进行转氨反应的能力
- 去除人胚肾细胞(HEK293)培养基中的谷氨酸
- 研究乳酸脱氢酶(LD)-丙氨酸转氨酶(ALT)酶偶联反应系统的动力学
生化/生理作用
谷丙转氨酶 (GPT) 存在于体内大多数细胞中，但在肝脏中浓度最高。由于在肝细胞坏死后 GPT 释放入血液，可作为肝脏疾病的标志物。
谷丙转氨酶（GPT）介导氨基从 l-丙氨酸转移到 α-酮戊二酸，从而产生丙酮酸和谷氨酸。因此，GPT 在糖异生和氨基酸代谢中发挥着关键作用。报道显示多种肿瘤中都有GPT参与。
外形
含柠檬酸盐和醋酸盐的冻干粉
制备说明
密闭。干燥。锁存或存放在只有合格或授权人员才能进入的区域
分析说明
双缩脲法测定蛋白质
其他说明
一个单位在-37°C、pH 7.6且L-丙氨酸存在条件下将 1.0μmol 酮戊二酸转化成 L -谷氨酸。
警示用语：
Danger
危险声明
预防措施声明
危险分类
Resp. Sens. 1
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
动植物源性产品
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A simple and sensitive detection of glutamic-pyruvic transaminase activity based on fluorescence quenching of bovine serum albumin
Chen M, et al.
Royal Society of Chemistry Advances, 5, 103557-103562 (2015)
A Comprehensive Guide to Toxicology in Nonclinical Drug Development
Faqi A S
Biomarkers journal., 2017 null
Giordano Pula et al.
Journal of biochemical and biophysical methods, 64(3), 167-181 (2005-08-23)
The surface expression of G protein-coupled receptors is regulated by internalization. For many receptors, a constitutive level of internalization in the absence of agonist has been reported. The constitutive internalization of metabotropic glutamate receptor 1a (mGluR1a) has been described, but
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