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G8291

Glu-Val-Asn-[(2R,4S,5S)-5-amino-4-hydroxy-2,7-dimethyloctanoyl]-Ala-Glu-Phe

Name: Glu-Val-Asn-[(2R,4S,5S)-5-amino-4-hydroxy-2,7-dimethyloctanoyl]-Ala-Glu-Phe
Brand: SIGMA

>93% (HPLC), solid

别名:

OM99-2

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关于此项目

经验公式（希尔记法）:

C₄₁H₆₄N₈O₁₄

化学文摘社编号:

314266-76-7

分子量:

892.99

NACRES:

NA.77

PubChem Substance ID:

329799977

UNSPSC Code:

12352200

MDL number:

MFCD03452932

Assay:

>93% (HPLC)

Form:

solid

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属性

assay

>93% (HPLC)

form

solid

solubility

0.1% trifluoroacetic acid: 1 mg/mL, clear, colorless

storage temp.

−20°C

SMILES string

CC(C)C[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CCC(O)=O)C(C)C)[C@@H](O)C[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(O)=O

InChI

1S/C41H64N8O14/c1-20(2)16-27(46-39(60)28(19-31(43)51)47-40(61)34(21(3)4)49-37(58)25(42)12-14-32(52)53)30(50)17-22(5)35(56)44-23(6)36(57)45-26(13-15-33(54)55)38(59)48-29(41(62)63)18-24-10-8-7-9-11-24/h7-11,20-23,25-30,34,50H,12-19,42H2,1-6H3,(H2,43,51)(H,44,56)(H,45,57)(H,46,60)(H,47,61)(H,48,59)(H,49,58)(H,52,53)(H,54,55)(H,62,63)/t22-,23+,25+,26+,27+,28+,29+,30+,34+/m1/s1

InChI key

NIOCOJFPGCXNKL-ZKZXETMPSA-N

说明

Biochem/physiol Actions

Inhibitor of brain β-secretase

存储类别

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor.

L Hong et al.

Science (New York, N.Y.), 290(5489), 150-153 (2000-10-06)

Memapsin 2 (beta-secretase) is a membrane-associated aspartic protease involved in the production of beta-amyloid peptide in Alzheimer's disease and is a major target for drug design. We determined the crystal structure of the protease domain of human memapsin 2 complexed

Design of potent inhibitors for human brain memapsin (β-secretase).

Ghosh, A.K.

Journal of the American Chemical Society, 122, 3522-3522 (2000)

Synthesis and Biological Activity of Some Benzochromenoquinolinones: Tacrine Analogs as Potent Anti-Alzheimer's Agents.

Mohammad Mahdavi et al.

Chemistry & biodiversity, 16(4), e1800488-e1800488 (2019-02-06)

Alzheimer's disease (AD) is a well-known neurodegenerative disorder affecting millions of old people worldwide and the corresponding epidemiological data emphasize the importance of the disease. As AD is a multifactorial illness, various single target directed drugs that have reached clinical

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全球贸易项目编号

货号	GTIN
G8291-.5MG	04061832981734