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Merck
CN

G8294

Sigma-Aldrich

Anti-Gonadotropin Releasing Hormone (GnRH) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

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MDL编号:
UNSPSC代码:
12352203
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生物来源

rabbit

偶联物

unconjugated

抗体形式

affinity isolated antibody

抗体产品类型

primary antibodies

克隆

polyclonal

表单

buffered aqueous solution

种属反应性

mouse

技术

immunohistochemistry: 1 μg/mL using mouse embryo brain

UniProt登记号

运输

dry ice

储存温度

−20°C

靶向翻译后修饰

unmodified

基因信息

human ... GNRH1(2796)
mouse ... Gnrh1(14714)
rat ... Gnrh1(25194)

免疫原

synthetic peptide pyroEHWSYGLRP(G-NH2) corresponding to human GnRH. The sequence is completely conserved in rat and tree shrew and 78% conserved in zebrafish.

应用

Anti-Gonadotropin Releasing Hormone (GnRH) antibody produced in rabbit is suitable for immunoprecipitation of GnRH purified from adult amphioxus tissues. It is suitable for immunohistochemistry at a working concentration of 1μg/mL using mouse embryo brain.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunocytochemistry (1 paper)

生化/生理作用

Gonadotropin releasing hormone (GnRH) is crucial for the regulation of reproduction in vertebrates. It is a decapeptide and is expressed by neurons in the medial basal hypothalamus (MBH) and secreted in a pulsatile manner into the cardiovascular system. Neural, hormonal and environmental stimuli affect the generation of GnRH pulses, which in turn affect the secretion of follicle stimulating hormone(FSH) and luteinizing hormone (LH) from the pituitary. It may be involved in mediating cancers of the reproductive system.

外形

Solution in phosphate buffered saline containing 1.0 mg/mL bovine serum albumin and 0.05% sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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储存分类代码

10 - Combustible liquids

WGK

nwg

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Erica E Davis et al.
Human molecular genetics, 29(14), 2435-2450 (2020-07-06)
Dysfunction of the gonadotropin-releasing hormone (GnRH) axis causes a range of reproductive phenotypes resulting from defects in the specification, migration and/or function of GnRH neurons. To identify additional molecular components of this system, we initiated a systematic genetic interrogation of
Jiao Zhu et al.
Journal of neuroscience research, 93(10), 1611-1621 (2015-06-19)
Gonadotropin-releasing hormone (GnRH) neurons play a pivotal role in reproductive function. GnRH is released in distinct pulses that are regulated by neurotransmitters or neuromodulators. With immunohistochemistry and GAD67-GFP knockin mice, this study shows for the first time that a subset
Angela Chambery et al.
Endocrinology, 150(2), 812-820 (2008-10-18)
GnRH, originally isolated from mammalian hypothalamus, is a key player in the control of vertebrate reproduction. Employing reverse-phase chromatography, we purified a peptide of relative molecular mass of 1182.60 Da from the cephalochordate amphioxus Branchiostoma lanceolatum. We found that its
J E Hall et al.
The Journal of clinical endocrinology and metabolism, 67(3), 524-531 (1988-09-01)
The differential regulation of immunoactive FSH and LH secretion by endogenous GnRH was studied using a GnRH antagonist, [Ac-D2Nal1,D4FPhe2,DTrp3,DArg6]GnRH (the NAL-ARG antagonist), in normal women in the early follicular phase of the menstrual cycle, and their responses were compared to
L Zhang et al.
Journal of neuroendocrinology, 29(5) (2017-03-16)
To study the mechanism by which monochromatic light affects gonadotrophin-releasing hormone (GnRH) expression in chicken hypothalamus, a total of 192 newly-hatched chicks were divided into intact, sham-operated and pinealectomy groups and exposed to white (WL), red (RL), green (GL) and

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